Translational Psychiatry
June 24, 2026
Mauro Pettorruso, Giacomo D’andrea, Antonio Inserra et al.
Clinical trials investigating psychedelic compounds for depression and anxiety-related disorders are yielding promising preliminary results. Psychedelics produce profound alterations in brain function—such as suppression of the default mode network and thalamocortical dysregulation—leading to intense subjective experiences including ego dissolution and mystical-type states. While often...
Cognitive, Affective, & Behavioral Neuroscience
June 23, 2026
Isaac N Treves, Clare Shaffer, Alexandra Decker et al.
Mind‑body practices, such as meditation and yoga, involve paying attention to breathing sensations. During these practices, individuals report "interoceptive lapses," moments when attention drifts away from internal bodily sensations. While lapses in attention to the external world have been widely studied, little is known about the physiological and neural mechanisms of interoceptive lapses....
The Medical letter on drugs and therapeutics
June 22, 2026
Auvelity (Axsome), an extended-release fixed-dose combination of dextromethorphan and bupropion that was approved by the FDA for treatment of major depressive disorder in 2022,1 has now been approved for treatment of agitation associated with dementia due to Alzheimer's disease (AD). It is the second product to be approved in the US for this indication; the oral second-generation antipsychotic...
JMIR Nursing
June 22, 2026
Gloria Guerrero-Pertiñez, Vera Carbonell, Jonathan Joseph Dawood-Histrova et al.
Background: Health care professionals are exposed to high levels of occupational stress, emotional exhaustion, and anxiety-depressive symptoms. Digital interventions using mindfulness- and acceptance-based approaches have shown promising results in improving psychological well-being in this population. The MINDxYOU program is a self-guided digital intervention designed to reduce perceived...
Mindfulness
June 22, 2026
Rose Seneviratne, Valerie Brandt, Matthew Garner et al.
Abstract Objectives Mindfulness-based programs (MBPs) are promising evidence-based interventions to mitigate the mental health crisis amongst young adults. This meta-analysis investigated MBPs’ impact on mental health outcomes and facets of mindfulness to inform the design of precise, evidence-based interventions addressing young adults' needs. Methods Systematic searches were conducted using...
Research Square
June 22, 2026
Limor Raviv, Ricardo Tarrasch, Reuven Dar
preprint
Abstract Objectives: This study examined the effect of a mindfulness-based intervention based on the Wheel of Awareness practice on psychological distress and access to internal states, within the framework of the Seeking Proxies for Internal States (SPIS) model of obsessive-compulsive disorder (OCD). The intervention aimed to enhance mindfulness skills, improve access to internal experiences,...
Nature Structural & Molecular Biology
June 22, 2026
Qianru Jiang, Jianming Han, Eve Fine et al.
Ketamine offers rapid relief for treatment-resistant depression and severe pain in the clinic, providing immediate benefits that traditional medications often fail to deliver. While its antagonistic action at the N-methyl-D-aspartate receptor (NMDAR) is a key mechanism, ketamine's dual nature as both a promising treatment and a drug with abuse potential suggests its therapeutic effects extend...
Pharmacological Reports
June 22, 2026
Magdalena Zaniewska
Serotonin (5-hydroxytryptamine; 5-HT) is a key neuromodulator involved in the regulation of mood, appetite, aggression, and impulse control. Dysregulation of central 5-HT function has been implicated in alcohol use disorder (AUD) and comorbid depression. This review summarizes clinical and preclinical evidence on the role of 5-HT in AUD development, heterogeneity, and treatment response....
Healthcare
June 21, 2026
Ebru Durusoy, Abdülhakim İbrahim Ulusoy, Özge Önürmen Zeyrek et al.
Background: Fibromyalgia is a chronic condition characterised by widespread pain, fatigue, sleep disturbances, and psychological symptoms. Mindfulness-based approaches are increasingly used as complementary interventions for symptom management. This study aimed to investigate the effectiveness of mindfulness-based yoga (MBY) delivered via telerehabilitation in individuals with fibromyalgia....
International journal of women's health
June 20, 2026
Songping Yi, Junyan Zhang, Aimin Li et al.
Objective: To evaluate the effect of mindfulness training in addition to essential psychological counseling on the clinical pregnancy rate in women undergoing frozen embryo transfer (FET), and to explore the potential mediating role of neuropsychological improvements. Methods and analysis: This study will be conducted as a single-center, parallel-group, open-label, exploratory randomized...