BACKGROUND: Posttraumatic stress disorder (PTSD) and major depressive disorder are often comorbid in humans. Psilocybin reportedly has beneficial therapeutic effects on depression, possibly by promoting neuroplasticity. PTSD is associated with the dysregulation of neuroplasticity in the hippocampus and medial prefrontal cortex (mPFC). We hypothesized that psilocybin might reduce fear memory by...
Abstract Cannabis use is linked to elevated psychosis risk, yet the neurobiological mechanisms that couple use to symptom expression remain unclear. Because glutamatergic dysregulation has been implicated in both cannabis effects and psychosis vulnerability, we examined whether brain glutamate relates to dimensional symptoms as a function of cannabis use across the psychosis spectrum....
Background: Cancer patients suffer from higher rates of psycho-social challenges. In the Indian context, their stress and psycho-social morbidities are often inadequately addressed. The researchers introduced a brief structured mindfulness group (Group M) therapy for them in a community cancer-care setting. The primary objective was to see an improvement in mental stress. Additionally, changes...
The integration of meditation practices into contemporary psychiatry reflects a shift from a reductionistic biomedical model to a more holistic approach to mental health. However, the epistemological transformation of Buddhist practices such as Vipassanā into a secular-psychological framework still leaves conceptual and methodological problems that have not been critically and comprehensively...
Introduction Postpartum depression is a common psychiatric morbidity with family-wide consequences. Mindfulness-Based Childbirth and Parenting (MBCP) program is a low-risk and cost-effective intervention suitable for Hong Kong’s work-oriented mothers. However, its unclear efficacy across mothers with varying levels of depressive symptoms limits its adoption. Objectives This post-hoc analysis...
Population aging demands accessible interventions for psychological well-being in later life. This work evaluated the feasibility and acceptability of an 8-week mindful walking program in community-dwelling older adults and generated exploratory estimates of within-person change across emotional, psychosomatic, and psychological outcomes. Thirteen community-dwelling older adults participated in...
Higher education students face unique stressors, including academic pressure, social challenges, and life transitions. These stressors can affect their mental health, academic performance, and overall well-being. Research has shown that high levels of stress can lead to anxiety, depression, poor sleep quality, and decreased academic motivation. This study investigates the effectiveness of an...
In the past decade, interest in studying psychedelic compounds as potential therapeutic agents has resurged. These studies carefully exclude individuals at risk for developing psychotic symptoms in response to psychedelic use. Given the potential for psychedelics to be established as treatments in psychiatry, it is important to more robustly understand their link with psychosis and...
Revista fisio&terapiaJune 25, 2026Daiane Lima de Lara Ziles, Jigliane Tainã Macedo de Souza, Yoda Janaina Ikenohuchi et al.
The treatment of resistant depression represents a significant challenge in psychiatry, as a considerable portion of patients do not adequately respond to conventional therapies. In this context, new psychedelic drugs have emerged as promising therapeutic alternatives, garnering increasing interest from the scientific and clinical community. The overall objective of this research is to analyze...
With the growing aging population and increased life expectancy, research must focus on enhancing not only longevity but also biopsychosocial well-being and positive aging. This study evaluated the effects of a structured Mindfulness and Compassion Program (MCP) on mental health, pain, mindfulness, self compassion, sleep, and social participation in older adults. Using a quasi-experimental...