РЕЗЮМЕ. Кетамін, відомий понад 60 років як дисоціативний анестетик, демонструє унікальний мультимодальний фармакологічний профіль, що виходить за межі класичного NMDA-антагонізму. Ця комплексна дія стала основою для його клінічної еволюції та «перевідкриття» у нових терапевтичних нішах, зокрема у психіатрії. Мета – систематизувати та проаналізувати наукові дані щодо клінічної еволюції кетаміну:...
Introduction. Limitations of conventional treatments for depression and anxiety, particularly in treatment-resistant cases, have driven interest in alternative therapeutic approaches. Psilocybin, a serotonergic agonist with demonstrated effects on neuroplasticity and large-scale brain networks, has emerged as a promising therapeutic option. Materials and methods: A systematic review of...
Reserveer ketamine of esketamine voor patiënten bij wie twee tot vier adequate antidepressieve behandelingen onvoldoende effect hebben gehad. Weeg ook de ernst mee; bij milde gevallen is dit doorgaans niet geïndiceerd. Overweeg esketamine bij acute suïcidaliteit bij therapieresistente depressie, ondanks de negatieve studieresultaten. De placebogroepen ontvingen uitstekende intramurale...
Reserve ketamine or esketamine for patients who have failed two to four adequate antidepressant trials. Weigh severity too; mild cases may not warrant it. Consider esketamine for acute suicidality in TRD despite the negative trial results. Placebo groups received excellent inpatient standard of care and improved substantially, masking the drug's benefit. Avoid ketamine and esketamine in active...
Translational PsychiatryApril 21, 2026Paul A Parcon, Amanda Bardhoshi, Amanda Olsen-Dufour et al.
The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine is a robust, rapid-acting antidepressant whose molecular effects have not been fully elucidated. Phosphodiesterase-4 (PDE4), which terminates cyclic adenosine monophosphate (cAMP) activity, may underlie antidepressant response. In particular, previous studies found that whole brain binding of the positron emission tomography (PET)...
Mindfulness-Based Interventions (MBIs) are widely used in primary care for pain and mental health, but gender-specific outcomes are under-researched. A systematic review was conducted using PRISMA 2020 guidelines. Studies from Scopus, Web of Science, and PubMed (1987-2023) with gender-disaggregated data were included. Elicit AI assisted in screening, data extraction, and thematic clustering....
Dear Editor, While there is a growing interest towards subconscious phenomena globally, experiences like lucid dreaming are under-researched in South Asia and remain largely unrecognized in Pakistan’s academic and clinical settings despite their widely acknowledged psychological significance. International studies have examined the association between lucid dreaming and psychopathology with...
Art TherapyApril 20, 2026Rebecca Ann Wilkinson, Alyssa B. Gursky
Renewal of research into psychedelics indicates their ability to provide relief from challenging conditions like trauma, treatment resistant depression, addictions, and end-of-life distress. Psychedelics appear to promote neuroplasticity, stimulate creativity, dampen fear responses, circumvent psychological defenses, soften rigid beliefs, and foster profound feelings of unity. The non-verbal,...
Despite the existence of current treatments for major depressive disorder (MDD), depression symptoms and burdens often persist, prompting the need for novel therapies, including psychedelic-assisted therapy (PAT), with promising potential for early and durable antidepressant responses. Objectives: This research aims to compare pharmacist opinions regarding logistical and ethical considerations...
Psilocybin simultaneously holds six contradictory legal classifications across jurisdictions: Schedule I (US federal), Breakthrough Therapy (FDA), legal therapeutic use (Oregon, Colorado), Schedule 8 medical use (Australia), and pending rescheduling review (DEA/HHS). This regulatory fragmentation constitutes a classification cascade—a multi-stage disruption propagated through administrative,...