Biologie aujourd'hui
2023
Philippe Fossati
Thirty percent of depressed patients are treatment resistant (TRD) suggesting the need of new therapeutic strategy. Recently, it has been shown that ketamine, an anesthetic agent with dissociative effects, has potent and rapid antidepressant properties. Ketamine is a ionotropic glutamatergic NMDA antagonist that inhibits gabaergic neurons. Its antidepressant effect peaks at 24 h post-treatment....
Complementary Medicine Research
2023
Wiebke Lehnert, Julia Günther-Pusch, Rainer Johannes Klement
Introduction: Anxiety, burnout, and depression cause a substantial psychological and social burden. Bioenergetic meditation (BM) was developed by Viktor Philippi as a method to strengthen psychological and physical health. This work presents the results of four feasibility studies investigating the effects of BM developed by Viktor Philippi as a support for people suffering from these...
International Journal of Nursing Studies
2023
Juan Li, Chang Li, Martine T E Puts et al.
BACKGROUND Lung cancer is one of the most common cancers and poses a physical and psychological threat to patients. Mindfulness-based interventions are emerging forms of psychotherapy that are effective in improving physical and psychological symptoms, but no review has summarized their effectiveness on anxiety, depression, and fatigue in people with lung cancer. OBJECTIVES To evaluate the...
Journal of Academic Research in Nursing
2023
Dilek Yıldırım, Özlem Akman
1 citation
The aim of this study is to assess the effect of mindfulness-based breathing-therapy on stress and well-being in individuals with chronic diseases. Methods: The study was conducted with single-blind randomised-controlled trial design and conducted with patients with chronic disease. 100 patients were randomly assigned to experimental (n=50) and control groups (n=50). Breathing-therapy received...
Journal of Clinical and Diagnostic Research
2023
Ajantha Antony, C Viji Prasad
Introduction: High levels of stress and anxiety are usually experienced by students as a result of peer pressure and concerns about college. Students who struggle to control their stress and anxiety may experience mood swings, behavioural changes, and even depression. Aim: To assess the effectiveness of mindfulness meditation on depression, anxiety, and stress among undergraduate nursing...
Mindfulness
2023
Barnaby D. Dunn, Hanna Wiedemann, Merle Kock et al.
Abstract Objectives Mindfulness-Based Cognitive Therapy for Depression (MBCT-D) has been shown to be effective at repairing positive affect deficits in depressed individuals, but the mechanism of action underpinning these changes has not been empirically examined. To address this issue, secondary analyses of two randomised controlled trials in individuals with residual depression were...
Progress in Brain Research
2023
Kenji Hashimoto
Neuroinflammation plays a key role in the pathogenesis of major depressive disorder (MDD), including treatment-resistant depression (TRD). Patients with TRD have higher levels of inflammatory biomarkers compared with responders to antidepressants. Multiple lines of evidence suggest that the gut-microbiota-brain axis via the vagus nerve plays a key role in neuroinflammation. Preclinical and...
Psychiatry Research
2023
Xuexiao Shao, Danfeng Yan, Wenwen Kong et al.
Nitrous oxide has rapid antidepressant effects in patients with treatment-resistant depression (TRD), but its underlying mechanisms of therapeutic actions are not well understood. Moreover, most of the current studies lack objective biological indicators to evaluate the changes of nitrous oxide-induced brain function for TRD. Therefore, this study assessed the effect of nitrous oxide on brain...
Frontiers in Psychiatry
2023
Emily Whinkin, Therry Rose J Eparwa, Michelle C Julseth et al.
Assess changes in symptoms of anxiety, depression, and psychosocial or spiritual distress before and after ketamine-assisted psychotherapy (KAP) in individuals with problematic substance use (PSU). A retrospective chart review was performed on participant data from two five-year prospective outcomes studies: the AIMS Medical Outcomes Study (AMOS) and the AIMS Cancer Outcomes Study (ACOS). The...
Frontiers in Psychiatry
2023
Alexander Kaltenboeck, Elisa Foerster, Sabrina Strafner et al.
A 28-year-old man was admitted to our psychiatric ward with severe obsessive-compulsive disorder (OCD) and comorbid depression. At intake, obsessive-compulsive symptoms were present most time of the day and were related to an intense fear of causing interpersonal misunderstandings. Various treatment attempts, including cognitive-behavioural therapy (CBT) with exposure and response prevention...
Journal of Behavioral and Brain Science
2023
Melissa C. Selinger, David M. Compton, Hamilton Morris et al.
3 citations
The management of patients with concomitant chronic pain (CP) and Major Depressive Disorder (MDD) remains challenging for clinicians. Current chronic pharmacologic management is often unsuccessful, or has intolerable side effects to the patients. While not restricted to patients with chronic pain, these patients are often diagnosed with depression, presenting with symptoms such as poor mood,...
Frontiers in Psychiatry
2023
Shanthi Sarma, Arulmathy Arunachalam, Memunatu Kamara et al.
6 citations
The following paper described two cases of patients with catatonic depression in bipolar disorder (BD) referred to our electroconvulsive therapy (ECT) service. Both were deemed not medically fit for ECT, and were, instead, treated with intravenous (IV) ketamine. Both responded with a resolution of symptoms, returning to baseline level of functioning. During the COVID-19 pandemic, given the...
Therapeutic Advances in Psychopharmacology
2023
Farhan Fancy, Sipan Haikazian, Danica E. Johnson et al.
23 citations
Background: The therapeutic potential of subanesthetic doses of ketamine appears promising in unipolar depression; however, its effectiveness in treating bipolar depression (BD) remains uncertain. Objective: This systematic review aimed to summarize findings on the use of ketamine for the treatment of BD by assessing its efficacy, safety, and tolerability. Design: Systematic review. Methods: We...
AIMS Public Health
2023
Aderonke Oyetunji, C. Blanco Huelga, Kailee Bunte et al.
9 citations
Depression and suicidality are significant challenges faced by cancer patients, particularly those in advanced stages of the disease or nearing the end of life. Conventional antidepressant therapies often have limited effectiveness or delayed onset of action, making the exploration of alternative treatments crucial. The use of ketamine as a potential treatment for depression and suicidality in...
Industrial Psychiatry Journal
2023
Pradhyuman Chaudhary, Prathmesh Shah, Prakash Mehta
4 citations
ABSTRACT Background: Depression is often a debilitating and recurrent psychiatric disorder. Depression with suicidal ideation, being a psychiatric emergency, often needs intensive intervention such as Electro-Convulsive Therapy (ECT). ECT may be refused because of stigma and perceived risk. Intravenous ketamine therapy, being an alternative to ECT for quick response compared to routine...
The Meducator
2023
Alam Mehrjerdi Zahra, Bhavana Soma
2 citations
Psilocybin is a naturally occurring compound present in numerous mushroom species characterised by its hallucinogenic and psychedelic effects. Although it has a negative reputation, psilocybin has demonstrated therapeutic potential for treating mental health disorders by allowing the brain to make new neural connections which help the neural pathways adapt and break out of certain cognitive...
Frontiers in Psychology
2023
Oiana Echabe-Ecenarro, Izaskun Orue, Esther Calvete
5 citations
Pregnancy is a time of major transition that can be stressful for women. Dispositional mindfulness may protect individuals when they face stress. Recent studies have adopted a person-centered approach to examine the role of mindfulness by identifying subtypes of individuals based on their scores in five mindfulness facets. Latent profile analysis was used to identify different mindfulness...
Frontiers in Psychiatry
2023
Philip E. Wolfson, Julane Andries, Daniel Ahlers et al.
27 citations
Ketamine-assisted psychotherapy is a promising new treatment for a variety of mental disorders of adolescence. There is currently an adolescent mental health crisis, with a high prevalence of disorders, diagnostic complexity, and many adolescents failing to respond to conventional treatments. While there is strong evidence for the use of ketamine in adults for a variety of treatment-refractory...
Global Advances in Integrative Medicine and Health
2023
Chelsea J Siwik, Shelley R Adler, Patricia J Moran et al.
7 citations
Mindfulness-based cognitive therapy (MBCT) is an effective group intervention for reducing rates of depression relapse. However, about one-third of graduates experience relapse within 1 year of completing the course. The current study aimed to explore the need and strategies for additional support following the MBCT course. We conducted 4 focus groups via videoconferencing, two with MBCT...
PLoS One
2023
Ahmed M Alzahrani, Ahmed Hakami, Ahmad Alhadi et al.
31 citations
There is growing interest in Mindfulness-based Stress Reduction (MBSR) program to combat mental distress in medical students. In Saudi Arabia, literature is insufficient about MBSR and its effectiveness. This study aims to measure the effectiveness of MBSR in improving mindful state, stress, anxiety, and depression in medical students. Also, the study explores the association between the...