Midwifery
July 1, 2022
T. Kuo, H. Au, Su-Ru Chen et al.
OBJECTIVE To evaluate the effects of an integrated childbirth education intervention on reducing childbirth fear, anxiety, and depression, and improving dispositional mindfulness. DESIGN A two-arm parallel, single-blind randomised controlled trial. SETTING A teaching hospital in Northern Taiwan. PARTICIPANTS Pregnant women ≥ 20 years of age with a singleton pregnancy (12-24 weeks gestation) and...
Psychiatry Research
July 1, 2022
Mu-Hong Chen, Chih-Ming Cheng, Cheng-Ta Li et al.
BACKGROUND This posthoc analysis compared the antidepressant and antisuicidal effects of low-dose ketamine infusion with those of repetitive transcranial magnetic stimulation (rTMS) on treatment-resistant depression (TRD). METHODS In the ketamine infusion trial, 48 patients with TRD were randomized to receive a single infusion of 0.5 mg/kg ketamine or normal saline. In the rTMS trial, 105...
Psychopharmacology
July 2022
Hildegard A Wulf, Caroline A Browne, Carlos A. Zarate et al.
Emerging evidence has implicated the endogenous opioid system in mediating ketamine's antidepressant activity in subjects with major depressive disorder. To date, mu opioid receptors have been suggested as the primary opioid receptor of interest. However, this hypothesis relies primarily on observations that the opioid antagonist naltrexone blocked the effects of ketamine in humans and rodents....
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
July 2022
Thomas J Moore, Abdallah Alami, G Caleb Alexander et al.
Ketamine, an anesthetic available since 1970, and esketamine, its newer S-enantiomer, provide a novel approach for the treatment of depression and other psychiatric disorders. At subanesthetic doses, the two drugs, along with their older congener, phencyclidine (PCP), induce a transient, altered mental state by blocking the N-methyl-D-aspartate (NMDA) receptor for glutamate, the primary...
Behavioural Brain Research
July 1, 2022
Li-Min Zhang, Na Liu, Lucy Cao et al.
BACKGROUND Anesthesia and psychotropic drugs in pregnant women may cause long-term effects on the brain development of unborn babies. The authors set out to investigate the neurotoxicity of S-ketamine, which possesses anesthetic and antidepressant effects and may cause attention deficit hyperactivity disorder (ADHD)- and depression-like behaviors in offspring mice. METHODS Pregnant mice were...
Iranian Journal of Psychiatry
July 1, 2022
Ahmad Shamabadi, Ali Ahmadzade, Ali Aqamolaei et al.
Objective: Available treatments of depression have limited efficacy and unsatisfactory remission rates. This study aims to review randomized controlled trials (RCTs) investigating effects of glutamate receptor modulators in treating patients with resistant depression. Method : The study protocol was registered in PROSPERO (CRD42021225516). Scopus, ISI Web of Science, Embase, Cochrane Library,...
Journal of Affective Disorders
July 1, 2022
Thomas D Hull, Matteo Malgaroli, Adam Gazzaley et al.
59 citations
BACKGROUND At-home Ketamine-assisted therapy (KAT) with psychosocial support and remote monitoring through telehealth platforms addresses access barriers, including the COVID-19 pandemic. Large-scale evaluation of this approach is needed for questions regarding safety and effectiveness for depression and anxiety. METHODS In this prospective study, a large outpatient sample received KAT over...
June 30, 2022
Ulrich Stangier, Elisabeth A. Arens, A. Frick
Das Manual integriert verschiedene Methoden zur Behandlung chronischer Depression unter einer prozessbasierten Perspektive. Zentraler Ansatzpunkt ist Wohlwollen als eine prosoziale Motivation, für sich selbst und anderen gegenüber Wohlbefinden und Glück anzustreben. Der Therapieansatz verbindet Metta-Meditation (Loving-Kindness-Meditation) und achtsamkeitsbasierte kognitive Therapie mit...
Behavioral Sciences
June 29, 2022
Letizia Iannopollo, Grazia Cristaldi, Caterina Borgese et al.
In the last decade, Mindfulness-based interventions have been increasingly used in health care settings, particularly in the context of cancer. Research documents the efficacy of these interventions for decreasing the burdens of stress, anxiety, depression, fatigue, sleep disorders, and other symptoms. This article describes the case report of a patient with breast cancer, highlighting her...
Child and Adolescent Mental Health
June 28, 2022
Nilija Fulambarkar, B. Seo, A. Testerman et al.
BACKGROUND Mindfulness-based interventions (MBIs) have been applied in school settings for adolescents with symptoms of stress, depression, and anxiety; however, general conclusions of the efficacy of such interventions remain unclear. This meta-analysis reviewed randomized-controlled MBI trials for stress, depression, and anxiety in school settings. METHODS One hundred one records were...
Frontiers in Pain Research
June 27, 2022
Dianna E. Willis, Peter A. Goldstein
6 citations
The phencyclidine-derivative ketamine [2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one] was added to the World Health Organization's Model List of Essential Medicines in 1985 and is also on the Model List of Essential Medicines for Children due to its efficacy and safety as an intravenous anesthetic. In sub-anesthetic doses, ketamine is an effective analgesic for the treatment of acute pain...
Journal of counseling and psychology
June 23, 2022
Jacob Schachter, Alex A. Ajayi, P. Nguyen
The COVID-19 pandemic has not only accounted for a substantial number of deaths in the United States but also deleterious mental health outcomes. We integrated multiple lines of previous research to better understand psychological strengths and difficulties in the face of the pandemic by testing a moderated mediation model that posited that rumination mediates the relationship between...
Neurology International
June 23, 2022
Islam Mohammad Shehata, Waniyah Masood, Nouran Nemr et al.
41 citations
Depression is a leading cause of disability globally, with a prevalence of 3.8% among the whole population, 5% of the adult population, and 5.7% of the elderly population over 60 years of age. There is evidence that depression is linked to certain neurodegenerative diseases, one being Alzheimer’s disease (AD). The efficacy of conventional antidepressants to treat depression in AD is...
Ca
June 16, 2022
D. Marinovic, Rebecca L. Hunter
Depression is highly prevalent in those diagnosed with cancer and is also associated with poorer prognostic outcomes. Mindfulness‐based interventions are effective in reducing depressive symptoms and improving quality of life in patients with cancer. The objective of this review was to investigate whether mindfulness practices can improve survival and, if so, what mechanisms of action may...
Brazilian Journal of Development
June 15, 2022
Marcus Solon Sá de Oliveira
Revisão sistemática sobre a eficácia da atenção plena como auxílio no tratamento de pensamentos automáticos em adolescentes. Problema da pesquisa: o que existe de pesquisas publicadas sobre o uso da atenção plena como auxílio no tratamento de pensamentos automáticos que levam a depressão em adolescentes? Objetivo: conhecer, mediante uma revisão sistemática de literatura, resultado de pesquisas...
Journal of Neurochemistry
June 9, 2022
Vern Lewis, Brandon Rodrigue, Emma J. Arsenault et al.
Ketamine has shown antidepressant effects in patients with major depressive disorder (MDD) resistant to first‐line treatments and approved for use in this patient population. Ketamine induces several forms of synaptic plasticity, which are proposed to underlie its antidepressant effects. However, the molecular mechanism of action directly responsible for ketamine's antidepressant effects...
Frontiers in Psychiatry
June 9, 2022
Holger C Bringmann, Martin Bogdanski, Georg Seifert et al.
6 citations
Background The scientific evaluation of mind-body-interventions (MBI), including yoga and meditation, has increased significantly in recent decades. However, evidence of MBI's efficacy on biological parameters is still insufficient. Objectives In this study, we used HRV analysis to evaluate a novel MBI as a treatment of outpatients with mild to moderate depressive disorder. The Meditation-Based...
Journal of Psychedelic Studies
June 9, 2022
Annie M. Mccartney, Hugh McGovern, Alexander de Foe
8 citations
Abstract Psychedelic substances such as psilocybin and ketamine may represent the future of antidepressant treatment, due to their rapid and prolonged effects on mood and cognition. The current body of psychedelic research has focused on administration and treatment within a psychiatric context. Here, instead, we put to the test the contention that it is necessary to evaluate the current state...
OBM Integrative and Complementary Medicine
June 7, 2022
Holly Hazlett-Stevens
Mindfulness-based stress reduction (MBSR) teaches mindfulness meditation to reduce stress, anxiety, depression, and related forms of distress among a variety of patients. Much research has documented statistically significant reductions across a variety of self-report measures following MBSR, but researchers rarely assessed and reported the clinical significance of MBSR symptom reduction in...
Journal of clinical psychology in medical settings
June 2022
Li-Ying Lin, Li-Hua Lin, Ghao-Ling Tzeng et al.
This meta-analysis was a systematic review of evidence on the effects of mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) on quality of life (QOL), pain, fatigue, anxiety, and depression in cancer patients. Until July 2020, PubMed, Cochrane Library, and Embase were searched for randomized controlled trials (RCTs). The study included 18 RCTs. The MBSR/MBCT...