BMC MedicineOctober 30, 2026Jiayi Lin, Fei Cheng, Lei Guo et al.
Abstract Background Impaired inhibitory control under negative affect is a core mechanism sustaining alcohol use disorder (AUD), but receives limited attention in treatment development. Mindfulness meditation has shown efficacy in improving this function, but outcomes differ across individuals. Transcutaneous auricular vagus nerve stimulation (taVNS) is a noninvasive neuromodulation approach...
Recent works such as REPA have shown that guiding diffusion models with external semantic features (e.g., DINO) can significantly accelerate the training of diffusion transformers (DiTs). However, the use of pretrained external features as guidance signals introduces additional dependencies. We argue that DiTs actually have the power to guide the training of themselves, and propose...
Attention is a crucial cognitive ability for sports performance. The current research aimed to investigate whether long-term mindfulness meditation (MM) intervention enhances male athletes' attentional function and alters the activity of brain regions related to attention. In this experiment, we recruited 47 professional male fencer athletes completed two main trials-an MM trial and a control...
Hearing loss affects communication and hinders personal attention and cognitive ability. We hypothesized that noise‐induced hearing loss (NIHL) patients during long‐term noise exposure may result in multimodal plastic changes in the nonauditory central nervous system.
With the improvement of people’s material conditions and the change of their values, sports consumption has shifted from hedonistic consumption, which simply pursues pleasurable experiences, to meaningful consumption, which seeks self-growth and life values. Meaningful sports consumption behavior has also received attention from scholars. The primary purpose of this study is to explore the...
The Psilocybe genus is well known for the synthesis of valuable psychoactive compounds such as Psilocybin, Psilocin, Baeocystin and Aeruginascin. The ubiquity of Psilocybin synthesis in Psilocybe has been attributed to a horizontal gene transfer mechanism of a ~20Kb gene cassette. A recently published highly contiguous reference genome derived from long read single molecule sequencing has...
BACKGROUND: Mindfulness-based interventions (MBIs) and cognitive behavioral therapy (CBT) have both been shown to be effective treatment approaches for anxiety. The purpose of this paper was to directly investigate the ability of MBIs and CBT to improve anxiety symptoms (primary outcome), as well as depression symptoms and sleep quality (second outcome). METHODS: We searched the following...
BACKGROUND Mindfulness-based cognitive therapy (MBCT) is an increasingly popular treatment for major depression and anxiety disorder, but has shown inconsistent efficacy for bipolar disorder (BD). Therefore, we conducted a meta-analysis to assess the general efficacy of MBCT for BD. METHODS Ten studies were identified that fulfilled the current inclusion criteria, including three controlled and...
A novel series of mGluR2 positive allosteric modulators (PAMs), 1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines, is herein disclosed. Structure-activity relationship studies led to potent, selective mGluR2 PAMs with excellent pharmacokinetic profiles. A representative lead compound (+)-17e demonstrated dose-dependent inhibition of methamphetamine-induced hyperactivity and...