bioRxiv (Cold Spring Harbor Laboratory)
September 25, 2018
Jacques D. Nguyen, Kevin M Creehan, Tony M Kerr et al.
9 citations
preprint
Abstract Adolescents are regularly exposed to Δ 9 -tetrahydrocannabinol (THC) via smoking, and, more recently, vaping, cannabis / extracts. Growing legalization of cannabis for medical and recreational purposes, combined with decreasing perceptions of harm, makes it increasingly important to determine the consequences of frequent adolescent exposure for motivated behavior and lasting tolerance...
Archives of Clinical Neuropsychology
September 22, 2018
Alexander L. Wallace, Natasha E Wade, Kelah Hatcher et al.
43 citations
OBJECTIVE: Research has demonstrated comorbidity between Attention-Deficit Hyperactivity Disorder (ADHD) and cannabis use, and some have proposed that subclinical ADHD symptoms may explain attentional deficits in cannabis users. Here we investigated whether subclinical ADHD symptoms and cannabis use independently or interactively predict performance on attention tasks in adolescents and young...
Human Brain Mapping
September 12, 2018
Feng Zhou, Kaeli Zimmermann, Fei Xin et al.
80 citations
The transition from voluntary to addictive behavior is characterized by a loss of regulatory control in favor of reward driven behavior. Animal models indicate that this process is neurally underpinned by a shift in ventral-dorsal striatal control of behavior; however, this shift has not been directly examined in humans. The present resting state functional magnetic resonance imaging (fMRI)...
Behavioural Pharmacology
September 7, 2018
P. Oomen, Hendrika H Van Hell, Matthijs G. Bossong
Cannabis remains the most frequently used illicit drug worldwide. It produces a broad range of acute effects, such as euphoria, increased heart rate and perceptual alterations. Over the last few decades, a substantial number of experiments have been conducted to provide insight into the acute effects of cannabis on cognition. Here, we systematically review studies that investigated the impact...
Talanta
September 6, 2018
Céline Burnier, Pierre Esseiva, Christophe Roussel
Nowadays, Gas Chromatography Mass Spectrometry (GC-MS) is mainly used in forensic sciences but suffers from limitations when the analysed compounds are thermally instable as it is the case for THC-A (Tetrahydrocannabinolic Acid) which is converted into Δ9-THC (Δ9-Tetrahydrocannabinol) that subsequently partially degrades. We propose herein a Fast High Pressure Liquid Chromatography...
Translational Psychiatry
September 5, 2018
Celia J. A. Morgan, Tom P. Freeman, Chandni Hindocha et al.
The main active ingredient in cannabis, delta-9-tetrahydrocannabinol (THC), can acutely induce psychotic symptoms and impair episodic and working memory. Another major constituent, cannabidiol (CBD), may attenuate these effects. This study aimed to determine the effects of THC and CBD, both alone and in combination on psychotic symptoms and memory function. A randomised, double-blind crossover...
Neurology
September 5, 2018
L. Weizman, Lior Dayan, Silviu Brill et al.
Objective To characterize the functional brain changes involved in δ-9-tetrahydrocannabinol (THC) modulation of chronic neuropathic pain. Methods Fifteen patients with chronic radicular neuropathic pain participated in a randomized, double-blind, placebo-controlled trial employing a counterbalanced, within-subjects design. Pain assessments and functional resting state brain scans were performed...
Psychological Medicine
September 4, 2018
Helen Valerie Curran, Chandni Hindocha, Celia J. A. Morgan et al.
65 citations
BACKGROUND: Changes in cannabis regulation globally make it increasingly important to determine what predicts an individual's risk of experiencing adverse drug effects. Relevant studies have used diverse self-report measures of cannabis use, and few include multiple biological measures. Here we aimed to determine which biological and self-report measures of cannabis use predict cannabis...
September 3, 2018
Michelle Newhart, William Dolphin
Chapter 5: Medical Cannabis Use in Everyday Life turns from the doctor’s office to how patients manage daily life, detailing how patients institute medicalized behaviors with cannabis. This chapter is the first of three based on the classic theory on drug use and extra-drug factors, “drug, set, and setting,” which proposes that a substance’s effects are due to not only the drug itself but also...
The Brown University Child & Adolescent Psychopharmacology Update
September 1, 2018
With more moves toward legalization of recreational cannabis, there is concern about adverse effects, including a possible link between cannabis use and psychosis. “Association of Cannabis Use with Adolescent Psychotic Symptoms,” a research letter published in JAMA Psychiatry, reports that there is a positive link between psychosis symptoms and cannabis use, with the cannabis use coming first.