Early Intervention in Psychiatry
August 10, 2022
Stephanie M. Woolridge, Chelsea Wood‐Ross, Rohit Voleti et al.
5 citations
AIM: Rates of cannabis use are elevated in early psychosis populations, rendering it difficult to determine if an episode of psychosis is related to cannabis use (e.g., cannabis-induced psychosis), or if substance use is co-occurring with a primary psychotic disorder (e.g., schizophrenia). Clinical presentations of these disorders are often indistinguishable, hindering assessment and treatment....
Clinical Toxicology
August 2022
Yasmin Schmid, Miguel Galicia, Severin B Vogt et al.
To investigate if clinical features associated with acute cannabis intoxication in patients presenting to Emergency Departments for medical assistance differ according to patient age and sex. We analysed presentations in the Euro-DEN Plus dataset from 2014 to 2019 in which cannabis was the only drug involved (except for alcohol), and age, sex and alcohol co-ingestion had been recorded. Age was...
The Canadian Journal of Psychiatry
August 1, 2022
Russell C. Callaghan, Marcos Sanches, Robin Murray et al.
Objective Cannabis legalization in many jurisdictions worldwide has raised concerns that such legislation might increase the burden of transient and persistent psychotic illnesses in society. Our study aimed to address this issue. Methods Drawing upon emergency department (ED) presentations aggregated across Alberta and Ontario, Canada records (April 1, 2015–December 31, 2019), we employed...
Addictive Behaviors
August 2022
Adrián F Amil, Belén Rubio Ballester, Martina Maier et al.
Chronic use of cannabis leads to both motor deficits and the downregulation of CB1 receptors (CB1R) in the cerebellum. In turn, cerebellar damage is often related to impairments in motor learning and control. Further, a recent motor learning task that measures cerebellar-dependent adaptation has been shown to distinguish well between healthy subjects and chronic cannabis users. Thus, the...
British Journal of Pharmacology
August 1, 2022
Michael Tagen, Linda E. Klumpers
The use of the intoxicating cannabinoid delta‐8‐tetrahydrocannabinol (Δ8‐THC) has grown rapidly over the last several years. There have been dozens of Δ8‐THC studies dating back over many decades, yet no review articles have comprehensively covered these findings. In this review, we summarize the pharmacological studies of Δ8‐THC, including receptor binding, cell signalling, in vivo...
Cannabis and Cannabinoid Research
July 26, 2022
Alberto Sainz-Cort, Daniel Jiménez‐garrido, Elena Muñoz Marrón et al.
9 citations
Background: Social cognition abilities such as empathy and the Theory of Mind (ToM) have been shown to be impaired in neuropsychiatric conditions such as psychotic, autistic, and bipolar disorders. The endocannabinoid system (ECS) seems to play a role in social behavior and emotional processing while it also seems to play a role in those neuropsychiatric conditions showing social cognition...
The Journal of Neuropsychiatry and Clinical Neurosciences
July 25, 2022
Raghav Shah, Abhishek Ghosh, A. Avasthi et al.
OBJECTIVE This study explored the differences in white matter (WM) microstructural integrity and gray matter (GM) volume between cannabis-induced psychosis (CIP) and schizophrenia with cannabis use (SZC). METHODS This cross-sectional study with convenience sampling involved three groups of 20 participants each (CIP, SZC, and a control group without substance use), matched on age, handedness,...
Psychiatry Research Case Reports
July 23, 2022
Jill M. Williams, Mary Barna Bridgeman, Lisa Laitman
Retracted
There is widespread support of cannabis for therapeutic purposes (CTP) despite lack of federal oversight and inconsistencies in screening, consenting, and authorizing use. Young people may have increased vulnerability to adverse effects including psychosis, substance use disorder, reduced academic achievement or other symptoms. We describe a case of a 20 year old who was prescribed CTP in the...
Biological Psychiatry
July 15, 2022
Randall J Ellis, Anissa Bara, Claudia A Vargas et al.
Cannabis remains one of the most widely abused drugs during pregnancy. In utero exposure to its principal psychoactive component, Δ9-tetrahydrocannabinol (THC), can result in long-term neuropsychiatric risk for the progeny. This study investigated epigenetic signatures underlying these enduring consequences. Rat dams were exposed daily to THC (0.15 mg/kg) during pregnancy, and adult male...
Cannabis
July 11, 2022
Brianna R. Altman, Mitch Earleywine, Maha N. Mian et al.
Links between cannabis use and psychosis generate research and media attention. Cannabis users have outscored non-users on the Schizotypal Personality Questionnaire-Brief (SPQ-B) in multiple studies, but previous work suggests that groups do not differ if biased items are removed. The present study examined links between schizotypal personality and cannabis use in a large sample recruited from...