JAMA Psychiatry
October 22, 2018
Nicole R. Karcher, Deanna M Barch, Catherine H. Demers et al.
52 citations
Importance: Previous research indicates that cannabis use is associated with psychotic-like experiences (PLEs). However, it is unclear whether this association results from predispositional (ie, shared genetic) factors or individual-specific factors (eg, causal processes, such as cannabis use leading to PLEs). Objectives: To estimate genetic and environmental correlations between cannabis use...
Pharmacology & Therapeutics
October 20, 2018
Michael Bloomfield, Chandni Hindocha, Sebastian F Green et al.
236 citations
receptor. Acutely, cannabis and THC produce a range of effects on several neurocognitive and pharmacological systems. These include effects on executive, emotional, reward and memory processing via direct interactions with the endocannabinoid system and indirect effects on the glutamatergic, GABAergic and dopaminergic systems. Cannabidiol, a non-intoxicating cannabinoid found in some forms of...
Biological Psychiatry
October 15, 2018
Sade M Spencer, Daniela Neuhofer, Vivian C Chioma et al.
Cannabis is the most widely used illicit drug, but knowledge of the neurological consequences of cannabis use is deficient. Two primary components of cannabis are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). We established a THC+CBD model of self-administration and reinstated drug seeking to determine if, similar to other addictive drugs, cannabis produces enduring synaptic changes in...
European Journal of Neuroscience
October 6, 2018
Shikha Prashad, Elizabeth S. Dedrick, Wing Ting To et al.
26 citations
The posterior cingulate cortex (PCC) and precuneus are hubs in the default mode network and play a role in processing external salient stimuli. Accordingly, activation in these regions has been associated with response to salient stimuli using drug cue-reactivity paradigms in substance using populations. These studies suggest that the PCC and precuneus may underlie deficits in processing...
The International journal on drug policy
October 1, 2018
Todd Subritzky
The cannabis academic literature is informed by dominant deficit, public health and harm reduction frameworks. However, a large majority of cannabis consumption appears to place outside the scope of these models that prioritise the identification and limitation of negative impacts. As such there are apparent analytical blind spots pertaining to: non-problematic use of cannabis (as defined by...
Drug and Alcohol Dependence
October 1, 2018
Kristen R Trexler, Sara R Nass, Molly S Crowe et al.
A subset of cannabis users develop some degree of Cannabis Use Disorder (CUD). Although behavioral therapy has some success in treating CUD, many users relapse, often citing altered sleep, mood, and irritability. Preclinical animal tests of cannabinoid withdrawal focus primarily on somatic-related behaviors precipitated by a cannabinoid receptor antagonist. The goal of the present study was to...
Neuroscience & Biobehavioral Reviews
October 2018
Marco Colizzi, Sagnik Bhattacharyya
Previous studies have reported conflicting results in terms of acute effects of cannabis in man. Independently of other factors, such discrepancy may be attributable to the different cannabis use history of study volunteers. It is thought that regular cannabis users may develop tolerance to the effects of acute cannabis administration. Here we systematically review all studies examining the...
bioRxiv (Cold Spring Harbor Laboratory)
September 29, 2018
Weihua Zhao, Kaeli Zimmermann, Xinqi Zhou et al.
1 citation
preprint
Abstract Background Deficient regulation of stress plays an important role in the escalation of substance use, addiction and relapse. Accumulating evidence suggests dysregulations in cognitive and reward-related processes and the underlying neural circuitry in cannabis dependence. However, despite the important regulatory role of the endocannabinoid system in the stress response, associations...
bioRxiv (Cold Spring Harbor Laboratory)
September 25, 2018
Jacques D. Nguyen, Kevin M Creehan, Tony M Kerr et al.
9 citations
preprint
Abstract Adolescents are regularly exposed to Δ 9 -tetrahydrocannabinol (THC) via smoking, and, more recently, vaping, cannabis / extracts. Growing legalization of cannabis for medical and recreational purposes, combined with decreasing perceptions of harm, makes it increasingly important to determine the consequences of frequent adolescent exposure for motivated behavior and lasting tolerance...
Archives of Clinical Neuropsychology
September 22, 2018
Alexander L. Wallace, Natasha E Wade, Kelah Hatcher et al.
43 citations
OBJECTIVE: Research has demonstrated comorbidity between Attention-Deficit Hyperactivity Disorder (ADHD) and cannabis use, and some have proposed that subclinical ADHD symptoms may explain attentional deficits in cannabis users. Here we investigated whether subclinical ADHD symptoms and cannabis use independently or interactively predict performance on attention tasks in adolescents and young...