British Journal of Pharmacology
2020
Jacques D. Nguyen, Kevin M Creehan, Tony M Kerr et al.
Adolescents are regularly exposed to ∆9 -tetrahydrocannabinol (THC) via smoking and, more recently, vaping cannabis extracts. Growing legalization of cannabis for medical and recreational purposes, combined with decreasing perceptions of harm, makes it increasingly important to determine the consequences of frequent adolescent exposure for motivated behaviour and lasting tolerance in response...
bioRxiv (Cold Spring Harbor Laboratory)
September 25, 2018
Jacques D. Nguyen, Kevin M Creehan, Tony M Kerr et al.
9 citations
preprint
Abstract Adolescents are regularly exposed to Δ 9 -tetrahydrocannabinol (THC) via smoking, and, more recently, vaping, cannabis / extracts. Growing legalization of cannabis for medical and recreational purposes, combined with decreasing perceptions of harm, makes it increasingly important to determine the consequences of frequent adolescent exposure for motivated behavior and lasting tolerance...
Psychopharmacology
September 2018
Mehrak Javadi-Paydar, Jacques D. Nguyen, Tony M Kerr et al.
Previous studies report sex differences in some, but not all, responses to cannabinoids in rats. The majority of studies use parenteral injection; however, most human use is via smoke inhalation and, increasingly, vapor inhalation. To compare thermoregulatory and locomotor responses to inhaled ∆9-tetrahydrocannabinol (THC), cannabidiol (CBD), and their combination using an e-cigarette-based...
Pharmacology, Biochemistry, and Behavior
September 2018
Jacques D. Nguyen, Yanabel Grant, Tony M Kerr et al.
A reduced effect of a given dose of ∆9-tetrahydrocannabinol (THC) emerges with repeated exposure to the drug. This tolerance can vary depending on THC dose, exposure chronicity and the behavioral or physiological measure of interest. A novel THC inhalation system based on e-cigarette technology has been recently shown to produce the hypothermic and antinociceptive effects of THC in rats. To...