Lasting effects of repeated ∆9 -tetrahydrocannabinol vapour inhalation during adolescence in male and female rats.
British Journal of Pharmacology January 1, 2020 Jacques D Nguyen, Kevin M Creehan, Tony M Kerr et al.
Adolescent rats repeatedly inhaling THC vapor developed tolerance to THC-induced hypothermia, with females showing tolerance earlier than males despite similar THC levels in the blood. In adulthood, both sexes retained tolerance, but THC potency was enhanced in females. Male rats exposed to adolescent THC ate more food than controls without gaining more weight. Adolescent THC exposure did not change oxycodone self-administration in either sex but increased fentanyl self-administration in females. The authors conclude that repeated THC vapor inhalation during adolescence has lasting consequences observable in adulthood.