Journal of Drug Abuse
2017
W. Thompson
Citation: Thompson WE (2017) In Summary: A High by Any Other Name: Exploring the Motivations for Consumption of ‘Legal Highs’. J Drug Abuse. Vol. 3 No. 2:10 A large number of legal, semi-legal, synthetic, and organic drugs are sold online and through commercial vendors as novelties, often bearing the label “not for human consumption.” This qualitative field study was based on extensive...
Journal of Clinical Psychopharmacology
December 2016
Martin A Katzman, Melissa Furtado, Leena Anand
Prevalence of psychiatric disorders continues to rise globally, yet remission rates and patient outcome remain less than ideal. As a result, novel treatment approaches for these disorders are necessary to decrease societal economic burden, as well as increase individual functioning. The recent discovery of the endocannabinoid system has provided an outlet for further research into its role in...
American Journal on Addictions
December 2016
David S. Mathai, Christopher D. Verrico, Daryl Shorter et al.
Certain medical consequences seem unique to synthetic cannabinoid (SC) and not cannabis use. We report the case of an adolescent, whose drug expectancies appear to minimize the severity of SC-related adverse events. An 18-year-old male presented with altered mental status and seizure, complicated by respiratory failure. He was stabilized and on discharge, despite counseling on the harms of SC...
Comprehensive Psychiatry
November 1, 2016
Paulo César Ribeiro Barbosa, Rick J. Strassman, Dartiu Xavier Da Silveira et al.
104 citations
Hoasca (also called ayahuasca) is a N,N-dimethyltryptamine (DMT) - containing psychedelic brew originally used for magico-religious purposes by Amerindian populations of the Amazon Basin. Recently, Brazilian syncretic churches have helped spread the ritual use of hoasca to Western societies. The aim of this study was to evaluate substance use, and neuropsychological and psychological...
Psychopharmacology
October 2016
Isabella Canazza, Andrea Ossato, Claudio Trapella et al.
AKB48 and its fluorinate derivate 5F-AKB48 are two novel synthetic cannabinoids belonging to a structural class with an indazole core structure. They are marketed as incense, herbal preparations or chemical supply for their psychoactive Cannabis-like effects. The present study was aimed at investigating the in vitro and in vivo pharmacological activity of AKB48 and 5F-AKB48 in male CD-1 mice...
Medicinski pregled
October 2016
Dušan Kolar, Michael V Kolar
Treatment-resistant mood and anxiety disorders require an intensive therapeutic approach, and it should balance benefits and adverse effects or other potential detrimental effects of medications. The goal of treatment is to provide consistent and lasting improvement in symptoms of depression and anxiety. Beozodiazepines are effective for anxiety symptoms, but with no sustained treatment...
Journal of Analytical Toxicology
September 1, 2016
Erica L. Bakota, Crystal Arndt, A. Romoser et al.
We present in this case report a validated method for accurate quantitative analysis of 3-methoxy phencyclidine (3-MeO-PCP) to determine postmortem blood concentrations of this PCP analog. A 29-year-old male with a history of illicit drug use was found unresponsive in his bed with a bag of white powder next to him. Resuscitation efforts were unsuccessful and the individual was pronounced dead 9...
BMC Psychiatry
August 18, 2016
Odd Martin Vallersnes, Alison M. Dines, David M Wood et al.
Psychosis can be associated with acute recreational drug and novel psychoactive substance (NPS) toxicity. However, there is limited data available on how common this is and which drugs are most frequently implicated. We describe a European case series of psychosis associated with acute recreational drug toxicity, and estimate the frequency of psychosis for different recreational drugs. The...
Journal of Pharmacology and Experimental Therapeutics
August 2016
Robert A Owens, Bogna M Ignatowska-Jankowska, Mohammed A Mustafa et al.
Whereas the inhibition of fatty acid amide hydrolase (FAAH) or monoacylglycerol lipase (MAGL), the respective major hydrolytic enzymes of N-arachidonoyl ethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), elicits no or partial substitution for Δ(9)-tetrahydrocannabinol (THC) in drug-discrimination procedures, combined inhibition of both enzymes fully substitutes for THC, as well as produces a...
Behavioural Pharmacology
August 2016
Jenny L Wiley, Timothy W Lefever, Nikita S Pulley et al.
Incomplete overlap in the discriminative stimulus effects of Δ-tetrahydrocannabinol (THC) and the endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol has been reported in food-reinforced tasks. The aim of this study was to examine cannabinoid discriminative stimulus effects in a nonappetitive procedure. Adult male mice lacking the gene for AEA's major metabolic enzyme, fatty acid...