Brain and Behavior
February 1, 2026
Burçin Ün, Zeki Akarsakarya, Özlem Yorulmaz Özü et al.
Previous studies have suggested that adenosinergic system in the central nervous system may play a role in both behavioral changes and the physiopathology induced by Δ9-tetrahydrocannabinol (THC), and this is thought to be mediated by adenosine A2A receptors (A2ARs). However, the contribution of the adenosinergic system to the anxiety-like behaviors in response to THC in mice is not well...
Pathophysiology
January 27, 2026
Fiorela Gorea, Martina Pelle, Federico Fiori Nastro et al.
Background/Objectives: Cannabis use has a particularly high prevalence in individuals with psychotic disorders. Although cannabis use is generally associated with cognitive impairments in the general population, its impact on cognition in psychosis remains controversial. This study aimed to investigate the association between cannabis use and cognitive performance in a cohort of individuals...
bioRxiv : the preprint server for biology
January 24, 2026
Kwang-Hyun Hur, Lisa D Nickerson, Jack Bergman et al.
preprint
Δ 9 -tetrahydrocannabinol (THC)-containing products are widely used recreationally, partly due to THC's ability to enhance the appetitive (i.e., rewarding) properties of diverse stimuli. However, the neural mechanisms through which THC modulates reward-related processing remain poorly understood. Here, we used a Pavlovian paradigm in adult squirrel monkeys (3males, 1female) to associate a...
BMC Psychology
January 21, 2026
Christina Chwyl, Angelica Spata, Will Lucas et al.
Findings indicate a "mindset-over-molecule" pattern wherein psychological context ("set") is more strongly associated with psychedelic outcomes than substance type alone.
Cochrane Database of Systematic Reviews
January 19, 2026
Gülay Ateş, Patrick Welsch, Petra Klose et al.
5 citations
Estimates of the population prevalence of chronic pain with neuropathic components range from 6% to 10%. Current pharmacological treatments for neuropathic pain help only a minority. New treatments are needed. Cannabis is increasingly promoted in the media as a treatment for chronic pain. This is an update of a review first published in 2018. To assess the benefits and harms of cannabis-based...
Journal of Cannabis Research
January 2, 2026
Sunitha Vemuri, Samantha M. Ayoub, Arpi Minassian et al.
Cannabinoids have proven to useful for attenuating adverse effects of HIV. People living with HIV use cannabis at higher rates, with evidence suggesting it alleviates physiological symptoms such as nausea, loss of appetite, etc.. Cannabis can alter physiology as well as essential behavioral functions such as motivation. This study investigated the effect of delta-9-tetrahydrocannabinol (THC),...
Journal of Psychoactive Drugs
2026
Michelle St Pierre, Stacey Squires, Sarah Daniels et al.
The increasing acceptance of cannabis use, and policy changes in several jurisdictions has led researchers and public health experts to call for a standard cannabis dose. Standard dosing units are useful tools for regulation, substance use guidelines, data collection, consistency of research, as a means of communicating low-risk recommendations and dose-related effects, and for self-monitoring....
Frontiers in Sports and Active Living
2026
Brandon A Ally, Paul A Mentele, Scott A Wylie
Cannabis use is increasingly common among collegiate athletes. While acute tetrahydrocannabinol (THC) effects are well documented, the chronic impact on game-speed cognition, defined as the ability to perceive, decide, and act within sub-second windows, remains poorly quantified. The current study examined whether chronic THC use degrades football specific game-speed cognition and reaction...
Contemporary Clinical Trials
2026
Christine A Rabinak, Paul E Kilgore, Mark A. Lumley et al.
Prolonged exposure (PE) therapy is effective for PTSD, yet dropout and partial response remain concerning. Preclinical and human studies suggest Δ9-tetrahydrocannabinol (THC) enhances fear extinction and recall through brain cannabinoid receptor activation in fear processing. Examine whether synthetic THC (dronabinol) augments PE effectiveness. Double-blind, placebo-controlled, trial with...
Clinical Neurophysiology Practice
2026
William T Creel, Colleen A Brenner, Richard E Hartman
Entropy analysis of electroencephalographic (EEG) data provides insight into the complexity of neural activity. This study primarily examined whether cannabis use frequency is associated with alterations in multiscale entropy (MSE) in the prefrontal cortex (PFC) and mapped baseline MSE differences across cortical regions. Resting-state EEG was collected from 57 adults: non-users (n = 18),...