Frontiers in adolescent medicine
March 26, 2026
S. Nichols, Kun Yang, D. Staley et al.
Introduction: Increased cannabis use in young adults may influence brain health and neurodevelopment. In the context of chronic HIV-associated neuroinflammation, however, mild cannabis use may attenuate negative outcomes through anti-inflammatory effects. More frequent cannabis use may remain deleterious to both young adults with HIV (YWH) and without HIV (YWoH). We explored cross-sectional...
Journal of Cannabis Research
March 24, 2026
F. Huppé-Gourgues, Natalie Spridzans, S. Lamarre et al.
Cannabis and its primary psychoactive component, Δ9-tetrahydrocannabinol (THC), are increasingly studied for their pharmacological effects, yet little is known about their pharmacokinetics in non-human primates. This study aimed to characterize the pharmacokinetic profile of THC and its metabolites following oral administration in vervet monkeys under both acute and short chronic exposure...
Schizophrenia Bulletin Open
March 18, 2026
M. Bandawar, M. Taylor, Isabel Morales-Muñoz et al.
Abstract Background and Hypothesis Affective instability (AffI) is associated with psychosis, and cannabis use is a known risk factor for psychosis. Previous evidence suggests that AffI may itself be a risk factor for cannabis use. This study aimed to investigate the longitudinal relationship between AffI and cannabis use during adolescence and the development of psychosis in early adulthood....
Scientific Reports
March 10, 2026
Bruna Brands, Adam Zaweel, Madison Wright et al.
Given the increasing availability of high-potency Δ9-tetrahydrocannabinol (Δ9-THC) products, understanding potency-related effects of Δ9-THC on driving performance is an important public safety issue. This randomized, double-blind, placebo-controlled, within-subjects trial examined the effects of smoked cannabis with varying Δ9-THC concentrations on simulated driving. Adults aged 19–45 who...
bioRxiv : the preprint server for biology
March 6, 2026
Natasha E Wade, Ryan M Sullivan, Alexander L. Wallace et al.
preprint
Adolescents experience extensive neurocognitive development, with cannabis use potentially impacting developmental trajectories. Here, we comprehensively assess the influence of adolescent cannabis use onset on neurocognitive trajectories and consider how recent delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) may influence neurocognition. We use the large, diverse longitudinal...
The American Surgeon™
March 2026
Jeremy Miller, Claudia Alvarez, Lauren Berki et al.
BackgroundCannabis use has increased in recent years, often perceived as therapeutic for psychiatric symptoms including those of posttraumatic stress disorder (PTSD). However, the relationship between pre-trauma tetrahydrocannabinol (THC) use and development of PTSD symptoms after injury remains poorly defined. The purpose of this study was to determine the association between THC use and...
Addiction
March 2026
Jack Chung, Daniel Stjepanović, Brandon Cheng et al.
Cannabis use is associated with psychiatric comorbidities, and the use of elta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) produces different neurophysiological and pharmacological effects. This study estimated the strength of associations between vaping of THC and CBD with depressive and anxiety symptoms in adolescents. Observational data were drawn from three years of the nationally...
Addictive Behaviors
March 1, 2026
Rachel L Gunn, Lindy K Howe, Holly K Boyle et al.
Cannabis has shown mixed results in its association with alcohol urge, which may be explained by individual differences. One such factor, working memory capacity (WMC) is associated with drug-related cue reactivity and implicated in alcohol use and problems. In the current study, we examined whether WMC moderates the acute effect of cannabis on alcohol urge in a randomized placebo-controlled...
Journal of Psychopharmacology
March 1, 2026
Carrie Cuttler, Ryan J Mclaughlin
One of the most robust acute effects of cannabis is impaired memory. Although memory is not a unitary construct, most cannabis research has focused on verbal memory. Less is known about its effects on more ecologically valid domains of memory, such as prospective and temporal order memory. We conducted a randomized, double-blind, placebo-controlled study to map out which aspects of memory are...
Psychopharmacology
March 1, 2026
Taren Mieran, Andrew Hill, Mark S Horswill et al.
Medicinal cannabis use is increasing worldwide, yet its impacts on driving safety in frequent users are not clearly understood. A more comprehensive understanding of the effects of THC on driving behaviour in frequent users is needed to guide drug driving policy and evidence-based advice for medicinal cannabis consumers. This study investigated the acute effects of orally ingested THC oil on...