Progress in Neuro-Psychopharmacology and Biological Psychiatry
March 1, 2025
Gabriela Visini, Rose Chesworth, Tim Karl
Increasingly, the cannabis sativa plant compound cannabidiol (CBD) is used to treat various psychiatric and neurological health conditions which occur in early life or adolescence, including schizophrenia and autism spectrum disorder. However, behavioural effects CBD during adolescence have received limited attention, and the long-lasting behavioural consequences of adolescent CBD treatment are...
Indian Journal of Psychiatry
March 1, 2025
Tathagata Mahintamani, Diptadhi Mukherjee, Debasish Basu
Background: Cannabis has been associated with psychopathology since ancient times, but controversies continue despite important advances in the field. This article is the fourth one in our decadal series of review articles that have been providing an update snapshot of the meandering journey of the research findings in this area. Aims: This narrative review of a comprehensive literature search...
Heliyon
February 21, 2025
Adrian Berk Safati, Wisam Almohamad Alkheder, Cassandra Justine Lowe et al.
To examine the effects of cannabis on mind-wandering, regular cannabis smokers of legally purchased pre-rolls took part in a three-session remote study. In each 30-min session participants completed three blocks of an attention task in which they pressed the spacebar in time with a metronome tone (the Metronome Response Task), and intermittently reported their levels of spontaneous and...
Psychopharmacology
February 10, 2025
Will Lawn, Xuejun Hao, Anna B. Konova et al.
2 citations
RATIONALE: Despite the critical role of choice processes in substance use disorders, the neurobehavioral mechanisms guiding human decisions about drugs remain poorly understood. OBJECTIVES: We aimed to characterize the neural encoding of subjective value (SV) for cannabis versus non-drug rewards (snacks) in people who use cannabis on a near-daily/daily frequency (PWUCF) and assessed the impact...
Psychopharmacology
February 7, 2025
Sabrina Zequeira, Emely A. Gazarov, Alara A. Güvenli et al.
With increasing legalization of recreational and medical cannabis, use of this drug is growing rapidly among older adults. As cannabis can impair cognition in young adults, it is critically important to understand how its consumption interacts with the cognitive profile of aged subjects, who are already at increased risk of decline. The current study was designed to determine how cannabis...
Clinical pharmacology and therapy
February 3, 2025
Andriy A Gorbenko, Jules A A C Heuberger, Maria J Juachon et al.
Emergency department visits due to cannabinoid‐induced toxicity, including acute cannabinoid intoxication (ACI) have increased worldwide as more states have liberalized cannabis policy. ACI symptoms include anxiety, panic attacks, tachycardia, and psychosis, primarily mediated through cannabinoid type 1 receptor (CB1) agonism by Δ9‐tetrahydrocannabinol (THC). This phase II randomized,...
JAMA Network Open
February 1, 2025
Daniel T. Myran, Michael Pugliese, Lyndsay D. Harrison et al.
Key Points Question Were the liberalization of medical cannabis and the legalization of nonmedical cannabis in Canada associated with changes in the population-attributable fraction of cannabis use disorders associated with schizophrenia? Findings In this population-based cohort study comprising 13 588 681 individuals, the population-attributable fraction of cannabis use disorder associated...
Cannabis and Cannabinoid Research
February 1, 2025
Margy Y. Chen, Emily B Kramer, Laurel P Gibson et al.
Objective: Cannabis has been touted for a host of pharmacological and therapeutic effects and users commonly report reduced symptoms of physical and mental health conditions, including anxiety, depression, and chronic pain. While there is existing empirical evidence supporting these effects of cannabis use, little is known about the extent to which these effects result from pharmacological...
Psychopharmacology
February 1, 2025
Maricela X. Martinez, Vanessa Alizo Vera, Christina M. Ruiz et al.
1 citation
Adolescent cannabis use is linked to later-life changes in cognition, learning, and memory. Rodent experimental studies suggest Δ9-tetrahydrocannabinol (THC) influences development of circuits underlying these processes, especially in the prefrontal cortex, which matures during adolescence. We determined how 14 daily THC injections (5 mg/kg) during adolescence persistently impacts medial...
Neuropsychopharmacology
February 1, 2025
Brian D Kangas, Harshawardhan U Deshpande, Sarah L Withey et al.
Although chronic cannabis use during adolescence can alter brain function and impair complex behavioral processes, it is unclear whether such deficits persist into adulthood. Using a coordinated awake neuroimaging and behavioral approach in nonhuman primates, we addressed this issue by examining the impact of chronic adolescent exposure to Δ9-tetrahydrocannabinol (THC) on brain functional...