Psychopharmacology
December 2025
Danielle McCartney, Jordan Levoux, Rebecca Gordon et al.
RATIONALE: Δ9-tetrahydrocannabinol (THC), the principal intoxicant in cannabis, is a highly lipophilic substance that is readily stored in fat. Preclinical research suggests that fat-stored THC can be released into circulation under lipolytic conditions, such as stress. However, compelling evidence of this phenomenon is lacking in humans. OBJECTIVES: Here, we investigated the effects of acute...
Journal of safety research
December 1, 2025
Bibiana Cardozo, Sarah Hartley, Nicolas Simon et al.
To investigate whether THC inhalation increases driving collisions, and to explore the relationship between car crashes and self-assessed driving ability as measured by Visual Analog Scales (VAS) and the Karolinska Sleepiness Scale, 30 male volunteers aged 18-30 years old, with a BMI of 18.5-26.2 Kg/m2, moderate tobacco and caffeine consumption, and at least one year of cannabis use either...
JAACAP open
December 1, 2025
Tram N B Nguyen, Benjamin A Ely, Aria Vitale et al.
Youth with depression use cannabis at high rates, and exposure to cannabinoids in adolescence has been shown to deleteriously alter the reward system. However, there has been sparse research on the link between adolescent cannabis use and anhedonia, a core symptom of depression and clinical manifestation of reward dysfunction. Here, in a sample of adolescents presenting predominantly with mood...
Cannabis and Cannabinoid Research
December 1, 2025
Sara R Westbrook, Allison L Jensen, Vanessa Copeland-Solorzano et al.
2 citations
The legalization of cannabis in several states across the United States has increased the need to better understand its effects on the body, brain, and behavior, particularly in different populations. Previous rodent studies have revealed age and sex differences in response to injected Δ9-tetrahydrocannabinol (THC). However, the pharmacokinetic and pharmacodynamic properties of THC administered...
International Journal of Innovative Research in Technology
November 11, 2025
Rashee Kapoor
Explore the article titled The Role of Cannabis in Indian Traditions and Its Evolving Perception Among Youth from IJIRT Volume 12, Issue 6. This study evaluates the effectiveness of teaching programs on waste management knowledge among women.
Journal of Psychopharmacology
November 3, 2025
Patricia Di Ciano, Bernard Le Foll, S. Zhao et al.
Background: Adults over the age of 65 years are the fastest growing group of cannabis users, but there are few studies of the acute effects of cannabis in this population. Aims: In the present naturalistic study, participants were invited to smoke their preferred legal cannabis in the lab prior to tests of verbal learning and memory, executive function and information processing, and functional...
Neuropsychopharmacology
November 2025
Edward Chesney, Dominic Oliver, Ananya Sarma et al.
In patients with schizophrenia, cannabis use exacerbates symptoms and can lead to a relapse of psychosis. Some experimental studies in healthy volunteers suggest that pre-treatment with cannabidiol (CBD) may reduce these effects, but others do not. Here, we investigated whether pre-treatment with CBD ameliorates the acute adverse effects of cannabis in patients with schizophrenia. Participants...
Pharmacology, Biochemistry, and Behavior
November 2025
Ariel Frajerman, Aude Marzo, Boris Chaumette et al.
Alterations in membrane lipids are well established in schizophrenia, and diet could be an accessible, modifiable etiological factor. We examined the influence of Polyunsaturated fatty acids (PUFAs) intake throughout the lifespan on behaviour in adult rats. We further explored a possible interaction with adolescent exposure to delta-9-tetrahydrocannabinol (THC), the lipidic psychoactive...
Early Intervention in Psychiatry
November 1, 2025
U. Chhagan, Vuyokazi Ntlantsana, E. Karim et al.
To describe the current and lifetime patterns of substance use, particularly cannabis, and its association with clinical presentation of individuals presenting with first episode psychosis, living with and without HIV, in KwaZulu‐Natal Province, South Africa.
Psychopharmacology
November 1, 2025
Marta De Felice, Hanna J Szkudlarek, Matthew J Jones et al.
RATIONALE: Chronic cannabis during adolescence is associated with long-lasting pathological outcomes, and these effects can be remarkably different between the sexes. Preclinical studies in rodents demonstrated that sustained exposure to Δ9-tetrahydrocannabinol (THC), induces sex-specific pathophysiological outcomes. Thus, while males exhibit higher vulnerability to schizophrenia-like...