Clinical Pharmacology & Therapeutics
July 1975
L E Hollister, H Gillespie
Oral doses of delta-9-tetrahydrocannabinol (THC) 20 mg, combined with placebo or with 40 mg dses of cannabinol (CBN) and cannabidiol (CBD), were given to volunteers. The combination of THC with CBN produced no detectable changes in the quality, intensity, or duration of the effects of THC alone. The THC-CBD combination tended to delay onset and prolong effects of THC, while making them somewhat...
Pharmacology
1975
I G Karniol, I Shirakawa, R N Takahashi et al.
The interaction of delta9-tetrahydrocannabinol (delta9-THC) and cannabinol (CBN) was studied in man. Five male volunteers were given placebo, 50 mg CBN, 25 mg delta9-THC, 12.5 mg delta9-THC + 25 mg CBN, and 25 mg delta9-THC + 50 mg CBN (orally). Administrations were spaced 1 week apart. With physiological measures, delta9-THC produced an increase in heart rate while CBN did not. When combined,...
Pharmacology, Biochemistry, and Behavior
1975
B G Henriksson, J O Johansson, Torbjörn U C Järbe
In an operant situation pigeons learned to peck one response key 90 min after an injection of 0.25mg/kg delta9-tetrahydrocannabinol (delta9-THC) and another key when trained nondrugged. When tested with doses of delta9-THC lwer than the training dose the birds disciminated 0.20 mg/kg of the drug from the nondrugged state but not 0.15 mg/kg or lower doses. The animals were able to discriminate...
Science
February 23, 1973
S Casswell, D F Marks
The effects of 3.3 and 6.6 milligrams of Delta(9)-tetrahydrocannabinol and of placebo on performance of three cognitive tasks were compared for naive subjects and experienced cannabis smokers. No differences in performance or reported subjective effects were found between these two groups. A significant decrement was found following dosage at both levels, replicating earlier findings of...
British Journal of Addiction to Alcohol & Other Drugs
September 1, 1972
Kenneth Davison, C. Helen Wilson
SummaryWhile the debate en whether cannabis is harmless or not continues it is helpful to record the casualties of its increasingly widespread use. A report is given of the occurrence of a prolonged psychosis in a University student in which cannabis smoking was thought to be a significant aetiological factor.
Science
February 4, 1972
D G Conrad, T F Elsmore, F J Sodetz
Delta(9)-Tetrahydrocannabinol, at doses within the effective range for humans, was administered orally to chimpanzees with stable, efficient timing performances maintained by multilink chained schedules of food reinforcement. Reinforcements decreased with increasing dose, because of decreased frequencies of total operant timing responses and decreased accuracy of the timing performances which...
Science
May 28, 1971
C H Hockman, R G Perrin, H Kalant
The administration of small doses of Delta(l)-tetrahydrocannabinol to cats with indwelling electrodes produced a disruption of both the electroencephalogram and behavior. Some of these alterations, including the appearance of a high-voltage slow wave electroencephalogram in the awake and moving animal, have been observed in cats that had been administered other drugs known to cause...
Canadian Psychiatric Association Journal
April 1, 1971
D. R. Campbell
Comparison was made among the electroencephalograms of eleven patients with psychotic reactions after the use of cannabis, twenty-nine patients admitted with a diagnosis of schizophrenia, ten for neurological consultations and eleven cannabis users with no apparent psychiatric implications. It was found that there was a greater increase in the EEG abnormalities of cannabis users than in the...
Clinical Pharmacology & Therapeutics
November 1, 1968
Leo E. Hollister, R. K. Richards, H. K. Gillespie
195 citations
A synthetic isomer of tetrahydrocannabinol (1‐Δ'‐3,4‐transtetrahydrocannabinol), believed to be identical to the most active naturally occurring THC, was compared with a semisynthetic THC‐like compound, synhexyl. Sixteen volunteer subiects received THC in doses ranging from 341 to 946 p.g per kilo gram (median 581). Thirteen subjects received synhexyl in doses ranging from 633 to 2,666 µg per...
Journal of Mental Science
October 1, 1958
Frances R. Ames
184 citations
This paper describes an inquiry into the effects of giving oral doses of the narcotic drug variously known as hashish, marihuana and, in South Africa, dagga. The drug is a preparation from the plant Cannabis sativa whose narcotic effect has been known for centuries. The writer's interest in it was inspired by the work in recent years on the mental disturbances produced by the active principles...