Cannabis and temporal disintegration in experienced and naive subjects.
S Casswell, D F Marks
Science February 23, 1973 DOI: 10.1126/science.179.4075.803 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Naive subjects and experienced cannabis smokers |
| Interventions | Delta(9)-tetrahydrocannabinol placebo |
| Dose | 3.3 mg and 6.6 mg |
| Topics | Cannabis |
| Key findings | Naive and experienced cannabis smokers did not differ in cognitive performance or subjective effects. THC at 3.3 mg and 6.6 mg significantly impaired performance on three cognitive tasks, replicating earlier findings of 'temporal disintegration' during cannabis intoxication. |
Abstract
The effects of 3.3 and 6.6 milligrams of Delta(9)-tetrahydrocannabinol and of placebo on performance of three cognitive tasks were compared for naive subjects and experienced cannabis smokers. No differences in performance or reported subjective effects were found between these two groups. A significant decrement was found following dosage at both levels, replicating earlier findings of temporal disintegration during cannabis intoxication.
Comparable studies
Other experimental studies on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Smoked Cannabis' Psychomotor and Neurocognitive Effects in Occasional and Frequent Smokers Occasional (<2x/week) and frequent (≥4x/week) cannabis smokers | 2015 | Controlled within-subjects study | n = 25 |
| Dissociable effects of cannabis with and without cannabidiol on the human brain’s resting-state functional connectivity Healthy volunteers experienced with cannabis but not regular users | 2019 | Within-subjects experimental design | n = 17 |
| Which biological and self-report measures of cannabis use predict cannabis dependency and acute psychotic-like effects? Young cannabis users | 2018 | Observational study (naturalistic, within-subject counterbalanced design) | n = 410 |
| Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects Healthy volunteers | 2018 | Experimental study | n = 5 |
| Coming off cannabis: a cognitive and magnetic resonance imaging study in patients with multiple sclerosis Patients with multiple sclerosis who began using cannabis after disease onset, used it... | 2019 | Quasi-experimental study with odd-even allocation | n = 40 |
Citations in the library
Cited by 7
- Δ9-Tetrahydrocannabinol (THC) impairs visual working memory performance: a randomized crossover trial. Neuropsychopharmacology October 1, 2020
- Δ 9 -Tetrahydrocannabinol (THC) impairs visual working memory performance: A randomized crossover trial bioRxiv (Cold Spring Harbor Laboratory) September 23, 2019
- Cannabis, lived time, and the disruption of temporal self-experience Frontiers in Psychiatry October 30, 2026
- Nabilone Impairs Spatial and Verbal Working Memory in Healthy Volunteers. Cannabis and Cannabinoid Research February 1, 2024
- Clinical, Cognitive, and Neurobiological Correlates of Impaired Timing Abilities Associate to Cannabis Use: a Systematic Review International Journal of Mental Health and Addiction August 29, 2023
and 2 more in the library