Phytotherapy Research
July 31, 2023
Giuseppe Tringali, Gianluca Lavanco, Valentina Castelli et al.
17 citations
Alcohol binge drinking is common among adolescents and may challenge the signalling systems that process affective stimuli, including calcitonin gene-related peptide (CGRP) signalling. Here, we employed a rat model of adolescent binge drinking to evaluate reward-, social- and aversion-related behaviour, glucocorticoid output and CGRP levels in affect-related brain regions. As a potential...
Neuroscience & Biobehavioral Reviews
July 1, 2023
Manoj K. Doss, Harriet de Wit, David A Gallo
30 citations
Psychoactive drugs modulate learning and emotional processes in ways that could impact their recreational and medical use. Recent work has revealed how drugs impact different stages of processing emotional episodic memories, specifically encoding (forming memories), consolidation (stabilizing memories), and retrieval (accessing memories). Drugs administered before encoding may preferentially...
Schizophrenia Bulletin
June 26, 2023
Anya K. Bershad, Harriet de Wit
12 citations
BACKGROUND AND HYPOTHESIS: Diminished social motivation is a negative symptom of schizophrenia and leads to severe functional consequences for many patients suffering from the illness. However, there are no effective medications available to treat this symptom. Despite the lack of approved treatments for patients, there is a growing body of literature on the effects of several classes of drugs...
Molecules
June 24, 2023
Daniela-Mădălina Ciucă Anghel, Gabriela Viorela Nițescu, Andreea-Taisia Tiron et al.
69 citations
Drug abuse and addiction are major public health concerns, with millions of people worldwide affected by the negative consequences of drug use. To better understand this complex issue, a review was conducted to examine the mechanisms of action and effects of drugs of abuse, including their acute and chronic effects, the symptoms of abstinence syndrome, as well as their cardiovascular impacts....
Frontiers in Psychiatry
May 12, 2023
Grace Blest‐hopley, Ben H Amit, Aisling O'Neill et al.
Editorial on the Research Topic Appropriateness and safety of using cannabinoid and psychedelic medicines as treatments for psychiatric disorders
International Journal of Environmental Research and Public Health
January 19, 2023
Koen Ponnet, Bert Hauspie, Nicky Dirkx et al.
21 citations
EDM event attendees are a high-risk population for substance use and associated adverse effects. The aim of this study was to examine substance use at EDM events, focusing on associations between attendance motives and substance use. Sociodemographic characteristics, event specifics, past-year use, and attendance motives were assessed through an online survey. Participants were 1345 Belgian EDM...
Frontiers in Pharmacology
2023
Moniek Schouten, Sebastiaan Dalle, Dante Mantini et al.
Cannabidiol (CBD) is a naturally occurring non-psychoactive cannabinoid found in Cannabis sativa, commonly known as cannabis or hemp. Although currently available CBD products do not meet the safety standards of most food safety authorities to be approved as a dietary supplement or food additive, CBD has been gaining widespread attention in recent years due to its various potential health...
Frontiers in Neuroscience
2023
Michael J Wesley, Joshua A Lile
Psychotropic drugs and transcranial magnetic stimulation (TMS) are effective for treating certain psychiatric conditions. Drugs and TMS have also been used as tools to explore the relationship between brain function and behavior in humans. Combining centrally acting drugs and TMS has proven useful for characterizing the neural basis of movement. This combined intervention approach also holds...
Pharmacology, Biochemistry, and Behavior
January 2023
Carley Marie Huffstetler, Brigitte Cochran, Camilla Ann May et al.
The behavioral effects of cannabidiol (CBD) are understudied, but are important, given its therapeutic potential and widespread use as a natural supplement. The objective of this study was to test whether a single injection of CBD affected anxiety-like or attention-like behavior, or memory in wildtype mice or mice with reported trait anxiety due to a targeted gene-deletion in a...
Neurobiology of Disease
2023
Marta Barrera-Conde, Emma Veza-Estévez, Maria Gomis-Gonzalez et al.
Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase that has emerged as a key regulator of neurotransmission in complex cognitive processes. Its expression is altered in treated schizophrenia patients, and cannabinoids modulate CDK5 levels in the brain of rodents. However, the role of this kinase, and its interaction with cannabis use in first-episode psychosis (FEP) patients is still...