Pharmacology
May 28, 2008
D.a. Kalbhen, G. Braun
The biogenic formation of certain methylated derivatives of catecholamines and serotonin have been discussed in causal connection with schizophrenia. Positive and negative results by various research groups in detecting 3,4-dimethoxyphenylethylamine (DMPEA) in urine of schizophrenics have led to contradictory interpretations of the importance of DMPEA in urine as an indicator of schizophrenia....
Pharmacology
2003
Gudrun Wakonigg, Katja Sturm, Alois Saria et al.
Although ‘ecstasy’ (3,4-methylenedioxymethamphetamine, MDMA) is, after marijuana, the second most prevalent illegal drug of abuse in European adolescents, animal experimental evidence of MDMA’s reinforcing effect has remained scarce, particularly in the rodent model, raising questions about the robustness of MDMA’s reinforcing effect under controlled laboratory conditions. In the present rat...
Pharmacology
2001
Elisabeth Ratzenboeck, Alois Saria, Norbert Kriechbaum et al.
97 citations
3,4-Methylenedioxymethamphetamine (MDMA; ‘ecstasy’) is one of the most prevalent illegal drugs of abuse among European adolescents, a population not generally experienced with respect to ‘hard’ drugs such as cocaine. We, therefore, determined the reinforcing effect of intravenously self-administered MDMA in a fixed ratio 1 time-out 150 s schedule of reinforcement in rats that were truly drug...
Pharmacology
November 1, 1998
S Sunder Sharma, Hemendra N. Bhargava
17 citations
The effects of ibogaine, an alkaloid isolated form the bark of the African shrub, Tabernathe iboga, and noribogaine, a metabolite of ibogaine, on morphine antinociception were determined in male Swiss-Webster mice. Mice were rendered tolerant to morphine by implanting them with a pellet containing 25 mg of morphine base for 3 days. Placebo pellet-implanted mice served as controls. The...
Pharmacology
June 1, 1995
Robert V. House, P T Thomas, Hemendra N. Bhargava
12 citations
The immunomodulatory potential of the indole alkaloids ibogaine and harmaline was examined in a panel of in vitro immune function assays. These assays were chosen to assess T-cell regulatory and effector function, B-cell function, macrophage function, and natural killer-cell function. The in vitro exposure to either ibogaine or harmaline resulted in a dose-related suppression of all immune...
Pharmacology
1977
R. K. Datta, W Antopol Dagger, Jagat J. Ghosh
1 citation
Incubation of brain cortex slices in the presence of glucose resulted in the permeation of about 65% of [14C] mescaline into slices. Of this, about one-third radioactivity was bound with nuclei, mitochondria, microsomes, and ribosomes. Dialysis of subcellular fractions did not markedly reduce the amounts of radioactivity bound to the fractions. The permeation into slices and the binding of...
Pharmacology
1975
Nandkumar S. Shah, Om D. Gulati
Incubation of rat brain homogenates or 14,500 g pellet isolated from the homogenate with (14C)-mescaline was associated with accumulation of (14C)-mescaline in the pellet. 1.33 mumol/ml of chlorpromazine, trifluoperazine, fluphenazine, imipramine, desmethylimipramine, nortriptyline and amitriptyline inhibited the accumulation of mescaline. Lower concentrations (0.133-0.44 mumol/ml) of the...
Pharmacology
1975
I G Karniol, I Shirakawa, R N Takahashi et al.
The interaction of delta9-tetrahydrocannabinol (delta9-THC) and cannabinol (CBN) was studied in man. Five male volunteers were given placebo, 50 mg CBN, 25 mg delta9-THC, 12.5 mg delta9-THC + 25 mg CBN, and 25 mg delta9-THC + 50 mg CBN (orally). Administrations were spaced 1 week apart. With physiological measures, delta9-THC produced an increase in heart rate while CBN did not. When combined,...
Pharmacology
1973
Alexander T. Shulgin, Thornton W. Sargent, Carolina Lopez Naranjo
33 citations
A rationale is presented for the investigation of the synthesis and pharmacology of 3-methoxy-4,5-methylenedioxyphenyl isopropylamine (MMDA) as a potential psychodysleptic compound; these experiments are reported. The chemical synthesis and physical properties of this compound are described. The pharmacologic effects of MMDA in several animal species are presented, as are its clinical effects...
Pharmacology
1972
Wojciech Kostowski, W Rewerski, T Piechocki
28 citations
The action of JB-336, psilocybin, ibogaine and bufotenine on the aggressiveness os isolated mice, as well as the muricide reaction of rats, was investigated. All drugs evoked a substantial decrease in aggressiveness, but this effect was dependent on isolation time, time after injection and the type of test used.
Pharmacology
1971
W Rewerski, Wojciech Kostowski, T Piechocki et al.
19 citations
The action of LSD, mescaline and Sernyl® onthe aggressiveness of isolated mice and killing reaction ofrats was investigated. At some dose range, LSD decreased the aggressiveness on isolation time. Mescaline was a strong in mice but not in rats whileSernyl slightly decreased the killing reaction and decreasedor increased the aggressiveness of mice according to dose level.
Pharmacology
1971
Alexander T. Shulgin, Thornton W. Sargent, C. Naranjo
A new centrally active halo-amine, 4-bromo-2,5 dimethoxyphenylisopropylamine, is described. In clinical evalua tion it proved to enhance effectively both emotional and in tellectual perception, without the imagery and perceptual distortions commonly encountered with many of the chemically related psychotomimetics. These properties suggest a potential valuable role in conjunction with...