D-[3H]LSD binds saturably, reversibly, and with a high affinity (KD = 10 nM) to rat brain membranes. The association and dissociation rates of binding are temperature dependent and fastest at 37 degrees C. Binding is enriched in crude microsomal (P3) membranes. D-[3H]LSD binding is stereospecific as L-LSD, the psychotropically inactive enatiomer, is 1000 times weaker than D-LSD as a displacing...
The effects of d-lysergic acid diethylamide (LSD) and chlorimipramine (CIMI) on the firing rate of serotonergic (5-HT) neurons and on the in vivo efflux of 5-HT were investigated in parallel. A cerebroventricular perfusing technique was used to measure the efflux of 3-H-5-HT formed in vivo from 3-H-tryptophan. Impulse flow in serotonergic neurons was monitored by single unit recording from...
Rat startle responses to air puffs were monitored in a stabilimeter during the intraventricular infusion of various doses of 5-hydroxytrptamine (5-HT) or the putative hallucinogenic congener of 5-HT, 5-hydroxy-N, N-dimethyltrytamine (5-HDMT) or saline. Qualitativity opposite effects were observed, with 5-HT producing a dose-dependent decrease in responsivity and 5-HDMT increasing the magnitude...
Modern psychology has treated the concept of Ego, hitherto regarded as something special, as a mere gestalt defined by the field of consciousness like all other objects.This is a great achievement of the modern psychology.Modern psychology has a great wealth of knowledge about the constancy of the world of perception, which includes the Ego, and has elucidated its laws.Accrding to these laws,...
A controlled investigation was made of the rehabilitative efficacy of brief residential psychedelic (LSD) psychotherapy with chronic heroin abusers. Seventy-eight volunteer addict inmates from Maryland correctional institutions were randomly assigned to the following: a treatment condition–psychedlic therapy (incorporating one high-dose LSD administration) during a six weeks residence in a...
Abstract— In rats treated with a monoamine oxidase inhibitor, (tranylcypromine), L‐ tryptophan produces a stereotyped syndrome of hyperactivity and hyperpyrexia due to an increased rate of brain serotonin (5‐hydroxytryptamine) synthesis. Pretreatment of rats with intraperitoneal injections of cycloheximide, acetoxycycloheximide, emetine and dehydroemetine and of mice with puromycin inhibited...
A stimulus generalization procedure was used to investigate the effects of LSD on sensitivity to auditory stimuli in rats. The shape of the generalization gradient was changed after administration of the drug only with a dose which produced decreases in relatively high rates of responding.
The relationship of the trophotropic and ergotropic systems of autonomic-somatic integration and their relevance to a variety of emotional states and levels of consciousness is reviewed. The importance of proprioceptive afferent feedback to the reticular formation and hypothalamus for the maintenance of ergotropic responsivity is indicated together with the beneficial clinical effects of...
Equivocal evidence exists as to the relationship of dream recall to field independence. Although previous work (Witkin, Dyk, Faterson, Goodenough, & Karp, 1962) showed field independents recalled more, Montgomery and Bone (1970) employing an Identical-figures Task obcained no such relationship. Considering these findings the present scudy was designed to clarify this area both by employing a...