Journal of Pharmacology and Experimental Therapeutics
July 1, 1982
Salomón Z. Langer, Chantal Moret
100 citations
Slices of rat hypothalamus prelabeled with [3H]-5-hydroxytryptamine ([3H]-5-HT) were superfused and the release of the labeled transmitter was elicited either by electrical stimulation or by fenfluramine. Whereas the electrically stimulated release of [3H]-5-HT was completely abolished by removing calcium from the superfusion medium, the fenfluramine-induced release of [3H]-5-HT was...
The Journal of Nervous and Mental Disease
May 1, 1982
Nancy H. Kerr, David Foulkes, Marcella Schmidt
82 citations
Ten college-educated young adults (four sighted, four congenitally blind, and two adventitiously blind) were studied in a sleep laboratory one night a week for 8 weeks. Dream reports were collected from electroencephalogram-defined sleep onset, rapid eye movement sleep, and non-rapid eye movement sleep, following a standard awakening schedule and interview format. Dream reports were analyzed in...
Psychopharmacology
March 1, 1982
Randall L. Commissaris, Richard H. Rech
The effects of diazepam quipazine, lysergic acid diethylamide (LSD), and 2,5-dimethoxy-4-methylamphetamine (DOM) were examined on a conditioned suppression paradigm. Food-deprived rats were trained to drink a liquid diet from a tube. Subsequently, intermittent 7-s tones were presented during the daily 10-min sessions, the tube being electrified during the last 5 s of each tone. The subject...
Neuroscience & Biobehavioral Reviews
1982
Randall L. Commissaris, M Davis
25 citations
The present studies examined the role of the spinal cord and the brain in mediating the effects of the hallucinogens N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) on the acoustic startle response in the rat. Systemic administration of these agents, which distributes to both the brain and spinal cord, produced opposite effects, as DMT depressed and 5-MeODMT...
Cortex
December 1, 1981
Nancy H. Kerr, David Foulkes
Our paper addresses, as did a recent study by Greenwood et al. (1977), the question of differential right vs. left hemispheric involvement in REM-sleep dreaming. A male subject with extensive lesioning of the right hemisphere and consequent contralateral homonymous hemianopia was studied for 2 nights in a sleep laboratory where a dream report was collected following each of 6 awakenings from...
Pharmacology, Biochemistry, and Behavior
October 1981
Randall L. Commissaris, Richard H. Rech
The present study examined the disruptive effects of the phenethylamine hallucinogen 2,5-dimethoxy-4-methylamphetamine (DOM) and the putative 5-hydroxytryptamine (5-HT) agonist quipazine on fixed ratio-40 (FR-40) operant responding alone or after pretreatment with putative 5-HT antagonist metergoline. Food-deprived male rats were trained to bar press on a FR-40 schedule for food reinforcements;...
Journal of Drug Education
June 1, 1981
Martin R. Wong, Nancye B. Brochin, Kay L. Gendron
Research evidence indicates relationships between anxiety and the use of psychoactive drugs, and between the practice of meditation and lowered physiological indices of anxiety. Ex-post-facto studies of meditators indicate a negative correlation between practice of meditation and drug use. In the present study, a non-self-selected sample of chemically dependent people was instructed in the...
Brain Research
June 1, 1981
The hypothesis that the action of hallucinogenic drugs is mediated by a depression of the activity of brain serotonergic (raphe) neurons was tested by examining the behavioral effects of several hallucinogenic drugs while concurrently monitoring the activity of raphe neurons in freely moving cats. LSD produced a dose-dependent decrease in raphe unit activity and a dose-dependent increase in...
Teratology
June 1, 1981
Kenneth S. Hirsch, Hans Fritz
19 citations
Abstract Mescaline was administered orally at doses of 16 and 32 mg/kg on the seventh through tenth days of gestation to pregnant cream‐strain hamsters. This treatment resulted in a dose‐dependent effect on reproductive success and skeletal ossification. The effect of mescaline on reproductive success included an increased number of resorptions resulting in a decreased litter size. The 32 mg/kg...
International Journal of the Addictions
May 1981
M S Jacob, P L Carlen, J A Marshman et al.
Phencyclidine (PCP) is a popular illicit drug often misrepresented as some other hallucinogenic substance and distributed in widely varying dosage forms and strengths. Users of hallucinogenic drugs may present with unintentional PCP overdoses. Toxicological laboratory analyses are essential to establish the diagnosis. In nine admitted overdose patients, the consciousness level ranged from alert...