Psychopharmacology
1987
D G Spencer, T Glaser, J Traber
69 citations
Male Wistar rats were trained to discriminate the interoceptive effects of 5-methoxy-N,N-dimethyltryptamine (5-OMe-DMT; 1.25 mg/kg, IP) from saline in a two-lever operant chamber. Following discrimination learning, the following drugs (with ED50 dose in mg/kg IP) dose-dependently generalized: lysergic acid diethylamide (LSD, 0.04), 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT, 0.11),...
The Journal of Nervous and Mental Disease
December 1, 1986
E M Bernstein, F W Putnam
Dissociation is a lack of the normal integration of thoughts, feelings, and experiences into the stream of consciousness and memory. Dissociation occurs to some degree in normal individuals and is thought to be more prevalent in persons with major mental illnesses. The Dissociative Experiences Scale (DES) has been developed to offer a means of reliably measuring dissociation in normal and...
Pharmacology, Biochemistry, and Behavior
December 1, 1986
R Young, John A. Rosecrans, Richard A Glennon
10 citations
Twenty-two rats were trained to discriminate either 1.5 mg/kg of 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a standard two-lever operant procedure. Once responding was stable, various doses of several serotonin (5-HT) antagonists, i.e., cyproheptadine (CYP), methysergide (UML), cinanserin (CIN), and methergoline (MCE), were administered in combination with 5-OMe DMT, to assess...
Journal of Psychoactive Drugs
October 1, 1986
John Buffum, Charles Moser
122 citations
(1986). MDMA and Human Sexual Function. Journal of Psychoactive Drugs: Vol. 18, MDMA: Proceedings of the Conference, pp. 355-359.
British Journal of Pharmacology
October 1, 1986
T Archer, W Danysz, G Jonsson et al.
16 citations
The effects of the alpha-adrenoceptor antagonists prazosin, phentolamine and yohimbine upon 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced analgesia were tested in the hot-plate, tail-flick and shock-titration tests of nociception with rats. Intrathecally injected yohimbine and phentolamine blocked or attenuated the analgesia produced by systemic administration of 5-MeODMT in all three...
Science
August 15, 1986
A Pfeiffer, V Brantl, A Herz et al.
The kappa opioid agonists are analgesics that seem to be free of undesired morphine-like effects. Their dysphoric actions observed with the kappa agonist cyclazocine are thought to be mediated by an action at sigma-phencyclidine receptors. The benzomorphan kappa agonist MR 2033 is inactive at sigma-phencyclidine receptors. In male subjects, the opiate-active (-)-isomer, but not the (+)-isomer,...
Pharmacology, Biochemistry, and Behavior
June 1986
E J Cone, R E Johnson, J D Moore et al.
Four healthy male subjects smoked two marijuana cigarettes or one marijuana cigarette and one placebo cigarette, or two placebo cigarettes on separate days in a random order crossover design. Each marijuana cigarette contained 2.8% delta-9-tetrahydrocannabinol (THC). Plasma hormones and THC were measured before and after each smoking session. Plasma LH was significantly depressed and cortisol...
Australian & New Zealand Journal of Psychiatry
June 1986
R R Kydd, J J Wright
This paper examines the classical functions of the psyche--cognition, affection and conation--from a phenomenological viewpoint and finds them to be defined each in terms of the other. It is held that this circularity of definition reflects the fundamental unity of conscious experience and, as a consequence, that the search for the biological substrate underlying individual functions too...
Journal of Pharmacology and Experimental Therapeutics
May 1, 1986
Wouter Koek, James H Woods, A. E. Jacobson et al.
Metaphit, a derivative of phencyclidine (PCP), binds irreversibly to PCP sites and appears to act as an antagonist of PCP under some conditions and as a PCP-like agonist under other conditions. To describe further these conditions, the authors investigated the behavioral effects of metaphit by using different routes of administration, behavioral procedures and species. In pigeons, metaphit...
Planta Medica
April 1, 1986
Marta Semerdžieva, M. Wurst, T. Koza et al.
20 citations
Psilocybin was quantitatively determined in methanolic extracts of dried fruiting-bodies of the basidiomycete Inocybe aeruginas-cens and its content was compared with that in Psilocybe bohemica and P. semilanceata. By menas of HPLC it was found that the content of psilocybin in Inocybe aeruginascens is lower than in Psilocybe species. Similarly to Psilocybe, the content of psilocybin in Inocybe...