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Pharmacology, Biochemistry, and Behavior February 1986 E F Domino
Before the advent of neuroleptics, opioids such as morphine were used occasionally in the treatment of schizophrenia and other mental disorders. Recent interest in the possible therapeutic role of endogenous opioid peptides in various mental states has prompted a new look at the opioids. The present paper summarizes the research to date in the author's laboratory on opioid-hallucinogen...
Journal of Neurochemistry 1986 J J Grome, A M Harper 40 citations
Substances with varying structural components have been shown to have 5-hydroxytryptamine (5-HT)-like properties in the CNS. In this study, putative 5-HT agonists with indoleamine moeities--lysergic acid diethylamide (LSD) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)--and with piperazine moieties--quipazine (Quip) and 6-chloro-2-(1-piperazinyl)pyrazine (6-CPP) were administered to rats....
Journal of Psychology and Theology December 1, 1985 John R. Finney, H. Newton Malony
The use of Christian contemplative prayer as an adjunct to psychotherapy was investigated It was hypothesized that (a) the use of contemplative prayer would he associated with improvement in psychotherapy; (b) the use of contemplative prayer would result in an enhancement of spirituality. A time series quasi-experimental design was used in which cacti subject served as his or her own control....
Pharmacology, Biochemistry, and Behavior October 1985 W D Wessinger, B R Martin, R L Balster
Four male Sprague-Dawley rats were trained to discriminate IP injections of 3.0 mg/kg phencyclidine (PCP) from saline under a 2-lever fixed-ratio 32 schedule of food presentation. After reliable discriminative control of lever choice was established, other doses of injected PCP were tested resulting in dose-dependent increases in PCP-lever selection and dose-dependent decreases in rates of...
Journal of Pharmacology and Experimental Therapeutics July 1, 1985 E. B. Nielsen
Four monkeys (Cercopithecus aethiops) were trained to discriminate 0.06 mg/kg of lysergic acid diethylamide (LSD) from saline in a two-key task in which correct responding was reinforced with food under a fixed ratio 32 schedule. The ED50 of LSD was 0.011 mg/kg. The nonhallucinogenic ergot, lisuride, and the hallucinogen, 5-methoxy-N,N-dimethyltryptamine, substituted completely for LSD (ED50...
Journal of pharmacological methods June 1, 1985 P Martin, H Frances, P Simon 21 citations
Intraperitoneal injection of 5-hydroxytryptophan and 5-methoxy-N,N-dimethyltryptamine is shown to provoke characteristic behaviors in mice that can be quantified. The two principal phenomena described here are head twitches and tremors. Tremors became more frequent when doses of the two substances studied were increased. Head twitches appeared at lower doses, but beyond a certain dose, they...
Pharmacology, Biochemistry, and Behavior May 1985 David J. Mokler, K W Stoudt, Richard H. Rech
Indolealkylamine and phenethylamine hallucinogens disrupted responding maintained under a fixed-ratio 40 (FR-40) schedule of reinforcement. LSD, DMT, mescaline and DOM produced dose-dependent decreases in number of reinforcers and increases in 10-sec periods of non-responding (pause-intervals). The 5HT agonist quipazine, as well as the LSD congener lisuride, altered response patterns in a...
Journal of Drug Issues April 1, 1985 William H. Mcglothlin 2 citations
This paper presents an argument for research into the means of altering individual attitudes, values, and communication abilities in the direction of increased social empathy, which, in turn, would produce a more favorable environment for resolving differences and facilitate peaceful negotiations between individuals and nations. It is proposed that prior research with the drug, d-lysergic acid...
Journal of Near-Death Studies 1985 Carl Becker 3 citations
This article presents a Tibetan perspective on near-death experiences (NDEs) and life after death.Tibetans have been concerned with death and deathbed visions from ancient times.After reviewing the beliefs of the Bon religion and of Vajrayana Buddhism, this article focuses on the theories of the Tibetan Bardo Thodol or Book of the Dead (Evans-Wentz, 1957).Many similarities to modern NDE reports...
Progress in Neuro-Psychopharmacology and Biological Psychiatry 1985 L M Adams, Mark A. Geyer
A previously proposed animal model of lysergic acid diethylamide's (LSD) effects in humans was tested for its applicability to other hallucinogens, 2,5-dimethoxy-4-methyl amphetamine (DOM) and N,N-dimethyltryptamine (DMT). Both "free" and "forced" exploration tests in a behavioral pattern monitor were used to determine the effects of these hallucinogens on the normal tendencies of rats to avoid...