Brain Research
August 26, 1996
R A Rabin, Jerrold C Winter
7 citations
The effects of the antiaddictive compound, ibogaine, and its primary metabolite, noribogaine (12-hydroxyibogamine), on phosphoinositide hydrolysis were investigated. Although ibogaine did not alter phosphoinositide turnover in either striatal or hippocampal slices, noribogaine elicited a concentration-dependent increase in the generation of [3H]inositol phosphates. This stimulation was not...
European Journal of Pharmacology
August 8, 1996
Richard T. Layer, Phil Skolnick, C M Bertha et al.
48 citations
Based on both preclinical findings and anecdotal evidence in man, the psychoactive indole alkaloid ibogaine has been suggested to have anti-addictive properties. Previous studies indicate that blockade of NMDA receptors may mediate at least some of the putative anti-addictive actions of ibogaine. The potencies of a series of ibogaine analogs to inhibit...
Synapse
August 1996
X M Gao, Carol A. Tamminga
Phencyclidine (PCP) is a psychotomimetic drug associated with acute and delayed mental effects in normal humans and psychosis exacerbation in already psychotic schizophrenic individuals. We have previously described a dose-sensitive, delayed action of PCP on regional cerebral metabolism in the rat which occurs over 48 hours and a late (24 hour) change in N-methyl-d-aspartate (NMDA) and kainate...
Neuropsychopharmacology
August 1996
J H Kehne, H J Ketteler, T C McCloskey et al.
(+/-)3,4-Methylenedioxymethamphetamine (MDMA) releases dopamine and serotonin in vivo and stimulates locomotor activity. Previous work demonstrated that MDMA-stimulated dopamine release could be reduced by the selective 5-HT2A receptor antagonist [R-(+)-a- (2,3-dimethoxyphenyl)-1-[2-(4-fluorophenylethyl)]-4-piperidinem ethanol] (MDL 100,907). In the present study MDL 100,907 significantly...
Psychopharmacology
July 1996
Aron H Lichtman, B R Martin
The purpose of the present study was to investigate whether the cannabinoid and cholinergic systems impair working memory through a common mechanism. This hypothesis was tested by examining whether the cannabinoid antagonist SR141716A would ameliorate radial-arm performance deficits caused by either the naturally occurring cannabinoid, delta 9-THC, or scopolamine, a muscarinic antagonist. In...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
July 1, 1996
Tracey Luxton, Linda A. Parker, S Siegel
13 citations
1. Ibogaine, a proposed anti-addictive agent, has been found to interfere with the acquisition of a weak morphine-induced place preference. The present series of experiments determined if ibogaine would interfere with the expression of a previously established morphine (5 mg/kg) place preference. 2. A single injection of 40 mg/kg of ibogaine 24 h, 12 h or 4 h prior to the preference test...
Alcoholism Treatment Quarterly
June 14, 1996
David Rioux
10 citations
This article constitutes an introduction to shamanic healing techniques as promoters of a holistic addiction counseling process. It describes the shaman as one who, by entering an altered state of consciousness, focuses on inner realities in order to find healing, harmony, wholeness for self and others. It pormays healing (i.e., Recovery from addiction) as a transformation of consciousness. It...
Philosophy, Psychiatry, & Psychology
June 1, 1996
G. Lynn Stephens
2 citations
Commentary on “Free Will in the Light of Neuropsychiatry” G. Lynn Stephens (bio) A necessary condition of our having free will is that we initiate some of our actions by our own will or decision. Spence argues that, in light of certain empirical findings, we can accept that willing causes action, only if we acknowledge that willing is a non-conscious phenomenon. “If the notion of free will is...
Drug and Alcohol Review
June 1, 1996
J M White, C F Ryan
Ketamine is a dissociative anaesthetic that is being used in non-medical contexts. The effects of ketamine are very similar to those of phencyclidine, another dissociative anaesthetic that has enjoyed considerable popularity as a recreational drug. The effects of ketamine include analgesia, cardiovascular and respiratory stimulation, dissociation, hallucinations and anaesthesia. The potential...
Brain Research
May 6, 1996
Stanley D Glick, Martin E. Kuehne, Isabelle M Maisonneuve et al.
118 citations
Ibogaine, a naturally occurring iboga alkaloid, has been claimed to be effective in treating addiction to opioids and stimulants, and has been reported to inhibit morphine and cocaine self-administration in rats. However, ibogaine also has acute nonspecific side effects (e.g. tremors, decreased motivated behavior in general) as well as neurotoxic effects (Purkinje cell loss) manifested in the...