The emergence of contemporary psychological stressors, synthetic psychoactive substance abuse, and non-substance behavioral dependency networks presents critical investigative challenges within public healthcare and classical toxicology (Agadatantra), traditionally analyzed through the concepts of Madya (intoxicants), Mada (intoxication), and severe cognitive perversion (Prajñāparādha). This...
Les troubles liés à l’usage de substances (TUS) touchent environ 2 % de la population mondiale et sont associés à une morbidité importante ainsi qu’à un risque de rechute élevé. Les envies impérieuses (le craving), définies comme une envie intense de consommer une substance, constituent une caractéristique centrale et transdiagnostique des TUS et représentent un prédicteur clé de rechute. Les...
Opioid use disorder (OUD) remains a major public health crisis in the United States, with mental health disorders substantially increasing risk severity. Emerging evidence suggests psychedelics may relate to reduced OUD risk. This exploratory study examined associations between lifetime psychedelic use and OUD severity and tested whether these associations varied by mental health impairment....
The serotonergic hallucinogen psilocybin has shown potential as a treatment for psychiatric conditions like alcohol use disorder (AUD) and depression in clinical studies. Epigenetic mechanisms, including DNA methylation, are hypothesized to contribute to its lasting therapeutic benefits. In this exploratory study, we present the first methylome-wide analysis of psilocybin-induced changes in a...
Addiction remains a major neuropsychiatric challenge, with dopaminergic, serotonergic, and GABAergic dysregulation underlying maladaptive behaviors. Traditional Brazilian medicinal plants offer a rich source of neuroactive compounds, yet their multi-target mechanisms remain underexplored. This study aimed to evaluate the neuropharmacological potential of harmine, caffeine, and damianin through...
Background: Positive psychology helps individuals enhance their attention, self-awareness, and positive thinking. Recent research has explored the impact of mindfulness—one of the core techniques in positive psychology—on behavioral addictions such as smartphone overuse. However, the effects of positive psychology courses that integrate mindfulness meditation, particularly in promoting digital...
An emerging approach called California Sober (CS) has gained attention for promoting abstinence of all intoxicating substances except cannabis and potentially, psychedelics. Cannabis legalization and the expansion of cannabis products have introduced new complexities in addiction recovery, challenging traditional abstinence-based frameworks such as Alcoholics Anonymous (AA), which define...
Background The prevalence of short video addiction is rising among college students, potentially exerting detrimental effects on their physical and mental wellbeing. Medical students, who experience relatively higher levels of academic stress, may be particularly susceptible to the adverse consequence of short video addiction. However, the specific factors influencing this addiction and the...
Summary This case report presents the case of a 25-year-old woman who developed ketamine addiction following a single sub-anaesthetic dose of intranasal ketamine in a pilot study investigating intranasal racemic ketamine for acute suicidality. She had a history of depression, obsessive–compulsive disorder, autism spectrum disorder and anorexia nervosa, and she had sporadically used alcohol and...