Introduction: Drug addiction is a chronic and relapsing disorder that has widespread socioeconomic and health consequences. Globally, there are over 29.5 million people who are drug dependent, and New Zealand has one of the highest rates of drug use rates in the developed world. Currently, there are no Food and Drug Administration (FDA) approved pharmacotherapies that target psychostimulant...
Psychiatriki2019K Laios, P Lytsikas-Sarlis, K Manes et al.
Drugs with psychedelic, hypnotic, narcotic, analgesic, suppressive, euphoric and stimulating effects were used in various ways during the ancient times. We can classify drug use in ancient times into two main categories. On the one hand, ancient physicians prescribed drugs based on their pharmaceutical-therapeutic actions. On the other hand, people not pertaining to medicine and not relating to...
Karl Friston's free energy minimization has been received with great enthusiasm. With good reason: it not only makes the bold claim to a unifying theory of the brain, but it is presented as an a priori principle applicable to living systems in general. In this article, we set out to show how the breadth of scope of Friston's framework converges with the dialectics of Georg Hegel. Through an...
The distinction between phenomenal and access consciousness has been influential in the field of consciousness studies. Both Block and Lamme proposed that access consciousness, or narrow cognitive accessibility, is related to a limited capacity working memory, and that phenomenal consciousness, or broad cognitive accessibility, is related to iconic memory or, more recently, to a fragile...
Richard Hayes (1993, 2013) and Dan Arnold (2008, 2012) have argued that Dharmakīrti (c. 600-660 C.E.) is a mind-body dualist. The proof, they say, lies in the justification he gives for his theory of rebirth. In this paper, I put Dharmakīrti’s argument to the test against a rival argument of Nāgārjuna. It turns out Nāgārjuna completely rejects the mind-body dualism of Dharmakīrti and the...
Reviewed by: The Trials of Psychedelic Therapy: LSD Psychotherapy in America by Matthew Oram Nicolas Rasmussen Matthew Oram. The Trials of Psychedelic Therapy: LSD Psychotherapy in America. Baltimore: Johns Hopkins University Press, 2018. xiv + 269 pp. Ill. $49.95 (978-1-4214-2620-4). The colorful history of the hallucinogen LSD has attracted the attention of numerous historians of medicine,...
Our previous results showed that a single oral dose (1 or 20 mg/kg body weight) of the anti-addiction agent ibogaine induced in rats 6 and 24 h after administration glycogenolytic activity in hepatocytes, followed by a mild oxidative stress. In this work, we examined the in vivo effect of the same doses of ibogaine on rat kidney morphology, antioxidant enzyme (superoxide dismutases (SOD1 and...
The bodily self is a fundamental part of human self-consciousness and relies on online multimodal information and prior beliefs about one's own body. While the contribution of the vestibular system in this process remains under-investigated, it has been theorized to be important. The present experiment investigates the influence of conflicting gravity-related visual and bodily information on...
Ibogaine is an atypical psychedelic alkaloid, which has been subject of research due to its reported ability to attenuate drug-seeking behavior. Recent work has suggested that ibogaine effects on alcohol self-administration in rats are related to the release of Glial cell Derived Neurotrophic Factor (GDNF) in the Ventral Tegmental Area (VTA), a mesencephalic region which hosts the soma of...
ACTIONS happen through consciousness. British researchers believe that experimental findings suggest consciousness could exist in the absence of a functioning brain. Many seekers testify to this observation that the microcosm is the macrocosm in miniature. Growth in the real sense enables a person to ‘see’ (or experience) the untapped potential. Energy can take many forms and may be transformed...