International Journal of Molecular Sciences
June 13, 2024
Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović et al.
6 citations
Ibogaine is an organic indole alkaloid that is used in alternative medicine to combat addiction. Numerous cases of life-threatening complications and sudden deaths associated with ibogaine use have been reported, and it has been hypothesized that the adverse effects are related to ibogaine's tendency to induce cardiac arrhythmias. Considering that the bioavailability of ibogaine and its primary...
Life (Basel, Switzerland)
December 23, 2021
Nikola Tatalović, Teodora Vidonja Uzelac, Milica Mijović et al.
8 citations
Ibogaine induces rapid changes in cellular energetics followed by the elevation of antioxidant activities. As shown earlier in male rats, ibogaine treatment with both 1 and 20 mg/kg b.w. per os led to significant glycogenolytic activity in the liver. In this work, female rats treated with the same doses of ibogaine per os displayed lower liver glycogenolytic activity relative to males,...
Antioxidants (Basel, Switzerland)
November 9, 2021
Nikola Tatalović, Teodora Vidonja Uzelac, Zorana Oreščanin-dušić et al.
5 citations
Ibogaine effects are mediated by cellular receptors, ATP depletion followed by ROS production and antioxidant enzyme activity elevation in a dose and time dependent manner. Since the role of KATP channels and β-adrenoceptors in ROS cellular circuit was established here we explored their role in ibogaine pro-antioxidant effectiveness. Single dose of ibogaine (10 mg/L i.e., 28.8 μmol/L) was...
IBRO Reports
December 1, 2019
Nikola Tatalović, Teodora Vidonja Uzelac, Zorana Oreščanin-dušić et al.
Ibogaine is the main alkaloid in the root bark of Tabernanthe iboga plant which groves in Western-Central Africa. It has been used by natives to overcome fatigue, hunger and thirst, and in higher doses to provoke hallucinations. In the “ibogaine medical subculture” in Europe and America it is used to facilitate abstinence from variety of addictive substances (cocaine, heroin, methadone,...
Archives of Biological Sciences
2019
Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović et al.
4 citations
Our previous results showed that a single oral dose (1 or 20 mg/kg body weight) of the anti-addiction agent ibogaine induced in rats 6 and 24 h after administration glycogenolytic activity in hepatocytes, followed by a mild oxidative stress. In this work, we examined the in vivo effect of the same doses of ibogaine on rat kidney morphology, antioxidant enzyme (superoxide dismutases (SOD1 and...
Archives of Biological Sciences
December 5, 2018
Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović et al.
7 citations
Ibogaine, administered as a single oral dose (1-25 mg/kg body weight), has been used as an addiction-interrupting agent. Its effects persist for up to 72 h. Ex vivo results showed that ibogaine induced cellular energy consumption and restitution, followed by increased reactive oxygen species production and antioxidant activity. Therefore, the aim of this work was to explore the effect of a...
Oxidative Medicine and Cellular Longevity
2018
Zorana Oreščanin-dušić, Nikola Tatalović, Teodora Vidonja Uzelac et al.
7 citations
Ibogaine is an indole alkaloid originally extracted from the root bark of the African rainforest shrub Tabernanthe iboga. It has been explored as a treatment for substance abuse because it interrupts drug addiction and relieves withdrawal symptoms. However, it has been shown that ibogaine treatment leads to a sharp and transient fall in cellular ATP level followed by an increase of cellular...