Provided herein are MDMA and their analogs for the potential psychotherapy-assisted treatment of alcohol use disorder (AUD), post-traumatic stress disorder (PTSD), and a method of predicting dosing and patient response.
Cannabis, a widely used psychoactive substance, can trigger acute cannabis-associated psychotic symptoms (CAPS) in people who use cannabis (PWUC). To assess rates and correlates of CAPS requiring emergency medical treatment, we analyzed data from an international sample of PWUC (n = 233,475). We found that 0.47% (95%CI 0.42; 0.52) PWUC reported lifetime occurrence of CAPS, defined as the...
In the modern industrial world, high-end technologies and large-scale social institutions have resulted in a fundamental separation between individuals, as well as between humans and the living world. Nowadays, our lives seem to completely dependent on a man-made world ? the economy, electric power, cars and highways, and the medical system; consequently, we depend more on the techno sphere...
Abstract Psychedelic serotonergic agonists such as psilocybin have recently been shown to produce sustained benefit in refractory depression, end of life anxiety, and addiction when administered in hallucinogenic doses and coupled with psychotherapy. Although it has been suggested that similar high-dose protocols may help chronic pain conditions, there are few published clinical trials of...
Genetic influences on acute responses to psychoactive drugs may contribute to individual variability in addiction risk. ABCB1 is a human gene that encodes P-glycoprotein, an ATP-dependent efflux pump that may influence the pharmacokinetics of delta-9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. Using data from 48 young adults (aged 19–25 years) reporting 1–4 days...
Abstract Background Ayahuasca's psychological and subjective effects were compared in rituals of two neoshamanic groups in Uruguay. Aims Compare, describe and analyze psychological effects and subjective experiences of ayahuasca ceremonies in two different groups: a psychospiritual holistic center, and a center specialized in substance use disorder's treatment. Methods A mixed...
Reviewed by: The Shaman's Wages: Trading in Ritual on Cheju Island by Kyoim Yun Maria Hasfeldt Long kyoim yun. The Shaman's Wages: Trading in Ritual on Cheju Island. Washington: University of Washington Press, 2019. Pp. ix + 240. In Korea, shamans are ritual professionals, which means that their livelihood is dependent on the ritual fees they charge their clients when hired by them. However,...
CureusSeptember 2022Sharvari J Joshi, Sabih N Khan, Jeet S Kantharia et al.
Background Stress is an episodic process in an individual's life that depends upon the circumstances that elicit this process, later jeopardizing an individual's mental balance and leading to depression and anxiety. Yoga is a traditional component of physical activity that contains three main domains, namely, maintaining the correct posture (asanas), control over one's breath (pranayama) and...
Melatonin (MEL), an indolamine with diverse functions in the brain, has been shown to produce antidepressant-like effects, presumably through stimulating neurogenesis. We recently showed that the combination of MEL with ketamine (KET), an NMDA receptor antagonist, has robust antidepressant-like effects in mice, at doses that, by themselves, are non-effective and have no adverse effects. Here,...
Abstract: This paper offers a novel argument against the phenomenal intentionality thesis (or PIT for short). The argument, which I'll call the extended mind argument against phenomenal intentionality, is centered around two claims: the first asserts that some source intentional states extend into the environment, while the second maintains that no conscious states extend into the environment....