Pain Medicine
December 10, 2024
Christopher L. Robinson, Pawan Solanki, S Snyder et al.
Known for their capacity to alter perception and consciousness, psychedelics are increasingly being explored for therapeutic applications in treating conditions such chronic pain, major depressive disorder, and post-traumatic stress disorder.1,2 Despite historical stigmas and legal restrictions, recent changes in legislation and the United States Food and Drug Administration (FDA) recognition...
Regional Anesthesia & Pain Medicine
August 5, 2024
Harman Chopra, Shravani Durbhakula, Alexander Shustorovich et al.
8 citations
Background/Importance Chronic pain affects many people globally, requiring alternative management strategies. Psilocybin is gaining attention for its potential in chronic pain management despite being classified as Schedule I. Objective This systematic review critically evaluates the evidence for psilocybin, a Schedule I substance, in the treatment of chronic pain. The exact purpose of the...
April 2, 2024
Harman Chopra, Timothy Furnish, Monica Verduzco-Gutierrez et al.
IntroductionCoronavirus disease 2019 (COVID-19) is a highly contagious respiratory illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus was first identified in Wuhan, China in December 2019 and has since spread
Pain
September 5, 2022
Matthew Lyes, Joel Castellanos, Timothy Furnish et al.
55 citations
Abstract Psychedelic serotonergic agonists such as psilocybin have recently been shown to produce sustained benefit in refractory depression, end of life anxiety, and addiction when administered in hallucinogenic doses and coupled with psychotherapy. Although it has been suggested that similar high-dose protocols may help chronic pain conditions, there are few published clinical trials of...
Regional Anesthesia & Pain Medicine
May 4, 2020
Joel Castellanos, C. Leonard Woolley, Kelly Bruno et al.
118 citations
The development of chronic pain is a complex mechanism that is still not fully understood. Multiple somatic and visceral afferent pain signals, when experienced over time, cause a strengthening of certain neural circuitry through peripheral and central sensitization, resulting in the physical and emotional perceptual chronic pain experience. The mind-altering qualities of psychedelics have been...
Neurocase
March 4, 2018
Vilayanur S. Ramachandran, Chaipat Chunharas, Zeve Marcus et al.
63 citations
AL's leg was amputated resulting in phantom-limb pain (PLP). (1) When a volunteer placed her foot on or near the phantom - touching it evoked organized sensations in corresponding locations on AL's phantom. (2) Mirror-visual-feedback (MVF) relieved PLP, as did, "phantom massage". (3) Psilocybin-MVF pairing produced synergistic effects, complete elimination of PLP, and reduction in paroxysmal...