Psychopharmacology
August 11, 2026
Madison Wright, Justin Matheson, Adam Zaweel et al.
RATIONALE Sex differences in the effects of cannabis have been demonstrated in animals, though the human evidence is more equivocal. In particular, more work is needed to better understand interactions between sex and dose in determining acute pharmacological effects of cannabis, especially at higher potencies of Δ9-tetrahydrocannabinol (THC). OBJECTIVES Sex differences were examined following...
Scientific Reports
March 10, 2026
Bruna Brands, Adam Zaweel, Madison Wright et al.
Given the increasing availability of high-potency Δ9-tetrahydrocannabinol (Δ9-THC) products, understanding potency-related effects of Δ9-THC on driving performance is an important public safety issue. This randomized, double-blind, placebo-controlled, within-subjects trial examined the effects of smoked cannabis with varying Δ9-THC concentrations on simulated driving. Adults aged 19–45 who...
Frontiers in neuroendocrinology
October 1, 2025
Justin Matheson, Danial Behzad, Christina Zakala et al.
5 citations
Acute cannabis exposure can transiently impair cognitive performance, increasing the risk of accidental injury and potentially disrupting activities of daily living. Although sex differences in responses to cannabis have been reported, no systematic review has examined whether these extend to acute cognitive effects. Our primary aim was to examine sex differences in the acute effects of...
Brain Sciences
September 3, 2022
Justin Matheson, Yollanda J. Zhang, Bruna Brands et al.
5 citations
Genetic influences on acute responses to psychoactive drugs may contribute to individual variability in addiction risk. ABCB1 is a human gene that encodes P-glycoprotein, an ATP-dependent efflux pump that may influence the pharmacokinetics of delta-9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. Using data from 48 young adults (aged 19–25 years) reporting 1–4 days...
Progress in Neuro-psychopharmacology and Biological Psychiatry
May 1, 2022
Christine M Wickens, Madison Wright, R. Mann et al.
Co-use of alcohol and cannabis is associated with increased frequency and intensity of use and related problems. This study examined acute effects of alcohol and cannabis on mood, subjective experience, cognition, and psychomotor performance. Twenty-eight healthy cannabis users aged 19-29 years with recent history of binge drinking completed this within-subjects, double-blind, double-dummy,...