Psychedelics belong to the oldest psychoactive drugs. They arouse recent interest due to their therapeutic applications in the treatment of major depressive disorder, substance use disorder, end-of-life anxiety,= and anxiety symptoms, and obsessive–compulsive disorder. In this review, the current state of preclinical research on the mechanism of action, neurotoxicity, and behavioral impact of...
Until recently, understanding the neurobiology of dreaming has relied upon on correlating a subjective dream report with a measure of brain activity or function sampled from a different occasion. As such, most assumptions about dreaming come from the neuroscience of rapid eye-movement (REM) sleep from which many, but not all, dream reports are recalled. Core features of REM sleep (intense...
This article shows the political adaptations of the yajé ritual in the Ecuadorian Amazon. It focuses on the siekopái's practices of resistance, negotiation, and self‐affirmation around three contemporary issues: the recognition of their ancestral territory, the demand for reparations for environmental damage resulting from oil exploitation, and the management of care during the COVID‐19...
Abstract Objective Can machine learning (ML) enable data‐driven discovery of how changes in sentiment correlate with different psychoactive experiences? We investigate by training models directly on text testimonials from a diverse 52‐drug pharmacopeia. Methods Using large language models (i.e. BERT) and 11,816 publicly‐available testimonials, we predicted 28‐dimensions of sentiment across each...
While there's been clinical success and growing research interest in hypnosis, neurobiological underpinnings induced by hypnosis remain unclear. In this fMRI study (which is part of a larger hypnosis project) with 50 hypnosis-experienced participants, we analyzed neural and physiological responses during two hypnosis states, comparing them to non-hypnotic control conditions and to each other....
Se muestra una revisión de investigaciones sobre adicciones. Se consideró especialmente la producción de literatura latinoamericana, donde las adicciones son abordadas desde perspectivas teórico-metodológicas que incluyen análisis provenientes de: ciencias sociales de la religión; etnografías sobre drogas; antropología médica. Particularmente, se profundiza en los modelos de tratamiento de las...
Abstract Ibogaine is an indole alkaloid derived from the root bark of Tabernanthe iboga. The anti-addictive actions of ibogaine were first reported in the 1960s by persons using heroin. They offered personal testimonials that single oral doses of ibogaine abruptly blocked opioid withdrawal, and they remained drug-free after ibogaine exposure. Today, online forums describe ibogaine use for...
Brazilian Journal of Health ReviewDecember 15, 2023Fernanda Leticia Dos Santos Matta, Vivian Frigo Batista, Alexandre Dantas Gimenes et al.
A Ibogaína é um alcalóide indólico psicoativo com efeitos estimulantes e alucinógenos o qual é derivado da casca da raiz do arbusto da África Ocidental Tabernanthe iboga, mostra-se uma alternativa promissora no tratamento de dependentes de substâncias derivadas do ópio por demonstrar uma afinidade significativa por muitos sistemas neurotransmissores. Avaliar os efeitos do tratamento com...
During binocular rivalry, conflicting images are presented one to each eye and perception alternates stochastically between them. Despite stable percepts between alternations, modeling suggests that neural signals representing the two images change gradually, and that the duration of stable percepts are determined by the time required for these signals to reach a threshold that triggers an...
Abstract Interest in psychedelics is increasing due to potential for improved mental health and quality of life. However, adverse effects on mental health are still a concern. Personality traits have been suggested to both influence the psychedelic experience and mental health, and even be changed by psychedelic use. The present study describes for the first time a national sample of Swedish...