Background: Anorexia nervosa (AN) is a severe psychiatric disorder with high morbidity, mortality, and relapse rates, most commonly emerging during adolescence. Despite specialized psychological and nutritional treatments, outcomes remain suboptimal, with high rates of relapse and chronicity. Psilocybin has been investigated with preliminary efficacy in other psychiatric conditions...
Scientific ReportsMarch 25, 2026Johannes Björkstrand, Emil Olsson, Oisín Hugh Clancy et al.
Fear-based disorders affect millions worldwide, yet current treatments show limited effectiveness for many patients. While mindfulness is increasingly used clinically for anxiety and trauma disorders, the neural mechanisms underlying its effects on fear processing remain unclear. We conducted a randomized controlled trial using 7T fMRI to test whether mindfulness training enhances fear...
Psychedelic experiences have been associated with improved quality of life, but many studies rely on samples of enthusiasts, raising concerns about selection bias. This study examined whether self-reported quality-of-life impact differed between a convenience sample of psychedelic enthusiasts and a general population sample recruited through Prolific, and whether sample differences persisted...
BACKGROUND: Adolescents are increasingly using classical psychedelics, yet little is known about how psychedelics use is related to their mental health. Emerging evidence suggests that adolescents may be more vulnerable to adverse outcomes in relation to psychedelic use compared to adults. This descriptive and exploratory study examined differences between adolescents and adults in reported...
Abstract A surge in societal and scientific discussion surrounds psychedelic research. One surprising fact keeps standing out: Many users report the psychedelic experience as a positive and lasting impact on their quality of life. The present study aimed to explore the quality and consequences of the most impacting psychedelic experience, with the user's Big Five personality in focus. This...
It is still unknown how current trends in psychedelic use among adolescents are related to mental health. This study reports on the prevalence of psychedelic use in a Swedish representative nationwide drug survey and its association with mental health outcomes and user personality. A cross-sectional study using data from the latest 2024 Swedish Council for Information on Alcohol and Other Drugs...
In the midst of growing research and societal discourse on psychedelic substances, a consistent finding is reported: A majority of users report profound personal meaning from their experiences. This pioneering study in Sweden, a nation renowned for its strict drug policies, sought to quantify the extent of reported meaningfulness among Swedish psychedelic users. Results revealed that a majority...
Interest in psychedelics is increasing due to the potential for improved mental health and quality of life. However, adverse effects on mental health are still a concern. Personality traits have been suggested to both influence the psychedelic experience and mental health, and even be changed by psychedelic use. The present study describes for the first time a national sample of Swedish...
In the midst of burgeoning research and societal debate regarding the impact of psychedelics on well-being, one key statistic stands out: Most users rate the psychedelic experience as one of the most meaningful in life. The present study aimed to investigate this using a questionnaire for the first time among Swedish psychedelic users. Results: The results showed that 58% regarded the...
Abstract Interest in psychedelics is increasing due to potential for improved mental health and quality of life. However, adverse effects on mental health are still a concern. Personality traits have been suggested to both influence the psychedelic experience and mental health, and even be changed by psychedelic use. The present study describes for the first time a national sample of Swedish...