Nature Communications
August 15, 2024
Davor Curic, Donovan M Ashby, Alexander McGirr et al.
9 citations
Scale-free statistics of coordinated neuronal activity, suggesting a universal operating mechanism across spatio-temporal scales, have been proposed as a necessary condition of healthy resting-state brain activity. Recent studies have focused on anesthetic agents to induce distinct neural states in which consciousness is altered to understand the importance of critical dynamics. However,...
Journal of Psychopharmacology
August 13, 2024
Kim Madden, Breanne Flood, Darren Young Shing et al.
13 citations
Background: Psychedelic drugs have been of interest in medicine since the early 1950s. There has recently been a resurgence of interest in psychedelics. Aims: The objective of this study is to determine the extent of the available literature on psilocybin for medical indications including the designs used, study characteristics, indications studied, doses, and authors’ conclusions. We identify...
European Neuropsychopharmacology
August 9, 2024
Friederike Holze, M. Madsen, Claus Svarer et al.
16 citations
The serotonin 2A (5-HT2A) receptor is an important target for drug development and the main receptor through which classical psychedelics elucidate their hallucinogenic effects. The 5-HT2A receptor antagonist ketanserin has frequently been used as a tool to block the receptor. Here, we establish the dose-occupancy relation of ketanserin and the cerebral 5-HT2A receptor in healthy participants...
Science
August 9, 2024
Min Chen, Shuangshuang Ma, Hanxiao Liu et al.
87 citations
Ketamine has been found to have rapid and potent antidepressant activity. However, despite the ubiquitous brain expression of its molecular target, the N-methyl-d-aspartate receptor (NMDAR), it was not clear whether there is a selective, primary site for ketamine's antidepressant action. We found that ketamine injection in depressive-like mice specifically blocks NMDARs in lateral habenular...
Kosmos
August 8, 2024
Izabela Szpręgiel
Dimethyltryptamine (DMT), which is a psychedelic substance, has been a target of neuropharmacological research for years, mainly because of its potential use in the treatment of psychiatric disorders. The pineal gland is the best studied organ for endogenous DMT synthesis. At the same time, the role of DMT has not been clearly established. The association of the pineal gland with endogenous DMT...
Kosmos
August 8, 2024
Maciej Lorenc
In the past decade, there has been a surge of interest in the therapeutic use of psychedelics, especially in the treatment of depression and addiction, resulting in many new research projects on their properties. This publication outlines the history of scientific experiments conducted with psychedelics in the 1950s and 1960s, as well as their subsequent international outlawing in the 1970s and...
Asian Journal of Pharmaceutical and Clinical Research
August 7, 2024
Yuvraj Kaushal, Pranav Goyal, Arshiya Sehgal
Objectives: Primary Objective: (1) The objectives of the study are as follows: assessment of the effectiveness of ketamine-based treatment in known patients of various subtypes of depression and (2) assessment of time of onset and duration along with routes of administration and safety of ketamine therapy. Secondary Objective: The objectives of the study are as follows: (1) evaluate changes in...
Communications Biology
August 5, 2024
Charlotte Maschke, Jordan O'Byrne, Michele Angelo Colombo et al.
50 citations
Consciousness has been proposed to be supported by electrophysiological patterns poised at criticality, a dynamical regime which exhibits adaptive computational properties, maximally complex patterns and divergent sensitivity to perturbation. Here, we investigate dynamical properties of the resting-state electroencephalogram (EEG) of healthy subjects undergoing general anesthesia with propofol,...
ACS Chemical Neuroscience
August 2, 2024
Fabio Urbina, Thane Jones, Joshua S. Harris et al.
9 citations
The development of new drugs addressing serious mental health and other disorders should avoid the psychedelic experience. Analogs of psychedelic drugs can have clinical utility and are termed “psychoplastogens”. These represent promising candidates for treating opioid use disorder to reduce drug dependence, with rarely reported serious adverse effects. This drug abuse cessation is linked to...
Current Topics in Medicinal Chemistry
August 1, 2024
Valerio Ricci, Domenico de Berardis, Giovanni Martinotti et al.
Background: Cannabis is the most widely used illicit substance. Numerous scientific evidence confirm the strong association between cannabis and psychosis. Exposure to cannabis can induce the development of psychosis and schizophrenia in vulnerable individuals. However, the neurobiological processes underlying this relationship are unknown. Neurotrophins are a class of proteins that serve as...