medRxiv Preprint Server
December 16, 2025
Derek Newman, Charlotte Maschke, George A. Mashour et al.
preprint
Background Propofol exposure can produce heterogenous neural responses, from the expected suppression to transient paradoxical excitation. EEG measures of signal complexity and entropy have emerged as reliable markers of consciousness, but different types of complexity and entropy measures are often conflated. We used Type I and II complexity measures on the Complexity–Entropy Causal Plane...
arXiv (Cornell University)
November 26, 2025
Jonas Mago, Josh Brahinsky, Mark Miller et al.
Criticality describes a regime between order and chaos that supports flexible yet stable information processing. Here we examine whether neural dynamics can be volitionally shifted toward criticality through the self-regulation of attention. We examined ten experienced practitioners of meditation during a 10-day retreat, comparing refined states of meditative absorption, called the jhanas, to...
Annals of Clinical and Translational Neurology
May 25, 2025
Charlotte Maschke, Loretta Norton, Catherine Duclos et al.
Accurate assessment of the level of consciousness and potential to recover in patients with severe brain injury underpins crucial decisions in the intensive care unit but remains a major challenge for the clinical team. The neurological wake-up test is a widely used assessment tool. However, many patients' behavioral responses during a short interruption of sedation are ambiguous or absent,...
Communications Biology
August 5, 2024
Charlotte Maschke, Jordan O'Byrne, Michele Angelo Colombo et al.
50 citations
Consciousness has been proposed to be supported by electrophysiological patterns poised at criticality, a dynamical regime which exhibits adaptive computational properties, maximally complex patterns and divergent sensitivity to perturbation. Here, we investigate dynamical properties of the resting-state electroencephalogram (EEG) of healthy subjects undergoing general anesthesia with propofol,...
bioRxiv : the preprint server for biology
October 31, 2023
Charlotte Maschke, Jordan O'Byrne, Michele Angelo Colombo et al.
7 citations
preprint
Consciousness has been proposed to be supported by electrophysiological patterns poised at criticality, a dynamical regime which exhibits adaptive computational properties, maximally complex patterns and divergent sensitivity to perturbation. Here, we investigated dynamical properties of the resting-state electroencephalogram of healthy subjects undergoing general anesthesia with propofol,...
Neuroimage
May 14, 2021
Catherine Duclos, Charlotte Maschke, Yacine Mahdid et al.
The development of sophisticated computational tools to quantify changes in the brain's oscillatory dynamics across states of consciousness have included both envelope- and phase-based measures of functional connectivity (FC), but there are very few direct comparisons of these techniques using the same dataset. The goal of this study was to compare an envelope-based (i.e. Amplitude Envelope...