Page 344 of 863: studies 3,431 to 3,440 of 8,627, newest first. Back to the addiction overview
August 30, 2024
Psychedelics generally elicit a profound change in consciousness, often with ego dissolution, mystical experiences, and enriched sensory perception, but are medically safe for most. Tachyphylaxis occurs after repeated psychedelic administration, preventing biological dependence. MDMA may have some abuse potential and less tachyphylaxis compared to LSD/psilocybin. Psychedelics have 5-HT2B...
Ecotoxicology and Environmental Safety August 30, 2024 Sen Zhao, Meng Liu, Jinyuan Chen et al. 1 citation
Novel Psychoactive Substances (NPS) derived from tryptamines has been detected in aquatic environments, leading to environmental toxicology concerns. However, the specific toxicological mechanism, underlying these NPS, remains unclear. In our previous work, we used 5-Methoxy-N-isopropyl-N-methyltryptamine (5-MeO-MiPT) as the representative drug for NPS, and found that, 5-MeO-MiPT led to obvious...
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology August 30, 2024 Gunnar Goerges, Paul Disse, Stefan Peischard et al. 2 citations
Over the years, the number of patients with neurodegenerative diseases is constantly rising illustrating the need for new neuroprotective drugs. A promising treatment approach is the reduction of excitotoxicity induced by rising (S)-glutamate levels and subsequent NMDA receptor overactivation. To facilitate the search for new NMDA receptor inhibitors neuronal cell models are needed. In this...
Addiction Science & Clinical Practice August 29, 2024 Lucinda A Grande, Tom Hutch, Keira Jack et al. 6 citations
Many people with opioid use disorder who stand to benefit from buprenorphine treatment are unwilling to initiate it due to experience with or fear of both spontaneous and buprenorphine-precipitated opioid withdrawal (BPOW). An effective means of minimizing withdrawal symptoms would reduce patient apprehensiveness, lowering the barrier to buprenorphine initiation. Ketamine, approved by the FDA...
Schizophrenia Bulletin August 27, 2024 Bianca Bianciardi, Helena Mastek, Michelle Franka et al. 6 citations
N-Methyl-d-aspartate receptor (NMDA-R) hypofunctioning has been hypothesized to be involved in circuit dysfunctions in schizophrenia (ScZ). Yet, it remains to be determined whether the physiological changes observed following NMDA-R antagonist administration are consistent with auditory gamma-band activity in ScZ which is dependent on NMDA-R activity. This systematic review investigated the...
Nature Communications August 23, 2024 David H. Sarrazin, Wilf Gardner, Carole Marchese et al. 41 citations
Depression is associated with dysregulated circadian rhythms, but the role of intrinsic clocks in mood-controlling brain regions remains poorly understood. We found increased circadian negative loop and decreased positive clock regulators expression in the medial prefrontal cortex (mPFC) of a mouse model of depression, and a subsequent clock countermodulation by the rapid antidepressant...
Pharmaceutics August 20, 2024 Guillaume Drevin, Maria Pena-Martin, Aurélien Bauduin et al. 4 citations
3,4-Methylenedioxymethamphetamine (MDMA) is a synthetic amphetamine derivative with notable psychoactive properties and emerging therapeutic potential, particularly for treating post-traumatic stress disorders (PTSD) and substance use disorders. However, its use remains controversial due to inter-individual variability influenced by both environmental and genetic factors. In this context,...
American Anthropologist August 19, 2024 Jim Weil
With its catchy title, historian Benjamin Breen's Tripping on Utopia brings together controversial findings about the human mind, social engineering, and professional responsibility.He delineates the time frame and focus of an inquiry into psychoactive drug research by stating that "Timothy Leary and the Baby Boomers did not usher in the first psychedelic era.They ended it" (3).The Controlled...
DergiPark (Istanbul University) August 19, 2024 Doğancan Sönmez, Aslı Enzel Koç
Psilosibin, klasik bir serotonerjik psikedelik madde olup, depresyon, anksiyete, travma sonrası stres bozukluğu, obsesif kompulsif bozukluk, yeme bozuklukları ve bağımlılık gibi ruhsal bozuklukların tedavisinde umut vaat etmektedir. Bu derleme, mevcut literatürü analiz ederek, psilosibinin terapötik etkilerini, olası mekanizmalarını ve klinik kullanımına dair etik ve yasal konuları ele...
Molecular Pharmacology August 16, 2024 Armida Miranda-Riestra, Montserrat G Cercós, Citlali Trueta et al. 4 citations
Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine secreted by the pineal gland during the dark phase of the photoperiod. Its main function is the synchronization of different body rhythms with the dark-light cycle. Research on melatonin has significantly advanced since its discovery and we now know that it has considerable significance in various physiological processes, including...