Neuroscience & Biobehavioral Reviews
October 1, 2025
Anna Vaslavski, Anna Harwood Gross, Salomon Israel et al.
1 citation
3,4-Methylenedioxmethamphetamine (MDMA) has been shown to enhance social cognition, partly through its effects on oxytocin, a neuropeptide involved in social cognition. Despite growing evidence linking MDMA to increased oxytocin levels, no study has systematically examined this relationship across different doses, times, and participant characteristics. This systematic review and meta-analysis...
eNeuro
October 1, 2025
Tanner L. Anderson, Artin Asadipooya, Pavel I. Ortinski
3 citations
Psychedelic drugs have garnered increasing attention for their therapeutic potential in treating a variety of psychiatric diseases, such as depression, anxiety, and substance use disorder. The claustrum (CLA), a brain area with remarkable interconnectivity to frontal cortices, has recently been shown to have a dense population of serotonin 2 receptors (5-HT2Rs) that are activated by...
Clinical Chemistry
October 1, 2025
Stephanie Marco
Abstract Background Psychedelic and dissociative drugs, including psilocybin, lysergic acid diethylamide (LSD), 3,4-methylenedioxymethamphetamine (MDMA), and ketamine, have garnered significant interest for their therapeutic potential in treating various mental health disorders. However, their psychoactive properties pose substantial risks when used in contexts requiring unimpaired cognitive...
September 30, 2025
Mariana Pereira
Dreaming is a universal yet poorly understood phenomenon. This thesis investigates the neural mechanisms of dream traits and states using multimodal neuroimaging, including structural and functional MRI, diffusion imaging, and simultaneous EEG/fMRI. By addressing methodological challenges and leveraging large-scale datasets, the studies provide novel insights into the neural correlates of dream...
Tehnologìï rozvitku ìntelektu
September 30, 2025
Denys Starkov
This article provides a critical analysis of the biologically reductionist model of addictive euphoria (“the high”) and demonstrates its methodological limitations. From a biological perspective, the dose–response relationship between psychoactive substances and emotional effects is not linear: research reveals plateau- and inverted-U-shaped curves, and excessive neurotransmitter activation...
Communications Biology
September 30, 2025
Yun Zhao, Naotsugu Tsuchiya, Mario Boley et al.
Waking levels of human consciousness are known to be supported by the integrity of complex structures and processes in the brain, yet how they are exactly regulated by neurobiological mechanisms remains uncertain. Here a space-time-resolved inference-based framework is applied to estimate the neurophysiological variables of a whole-cortex model and analyze the neural mechanism correlates of...
Psikiyatride Güncel Yaklaşımlar
September 30, 2025
Mahir Mutlu, Çağrı Öven, Bilge Sena Kurt et al.
Major depressive disorder is a public health issue that negatively impacts quality of life and leads to cognitive impairments, causing significant disruptions in work, education, and social life. Treatment-resistant depression is defined as the failure to achieve improvement in depressive symptoms despite the use of at least two different antidepressant medications at adequate doses and...
Nature Communications
September 30, 2025
Cassandra J. Hatzipantelis, Min Liu, A. H. G. Love et al.
2 citations
Abstract Psilocybin increases social connectedness and has strong clinical transdiagnostic efficacy for mental illness, making it a candidate treatment to reduce maternal disconnect, anxiety, and blunted affect seen in peripartum mood disorders. However, the efficacy and safety of psilocybin in peripartum mood disorders has not been investigated. We used a social stress model to examine the...
Communications Psychology
September 29, 2025
John P Veillette, Yimeng Cheng, Aditi Joshi et al.
The nature of self-awareness has been a topic of inquiry for thousands of years, with profound implications for law and ethics, as well as for understanding a host of neurological and psychiatric pathologies. An influential view in philosophy of mind is that the "self" is a construct of consciousness, its basic functions - such as the sense of agency, the capacity by which we attribute sensory...
Harm Reduction Journal
September 29, 2025
Yen-Chun Kuo, Sheng-Chang Wang, Chuan-Yu Chen
The misuse of ketamine, a dissociative anesthetic, has surged sharply in popularity across East and Southeast Asia and Oceania. This study aimed to evaluate the association between recent patterns of ketamine use and the risk of suicide in northern Taiwan. Illicit ketamine users were recruited through network-based sampling from 2015 to 2017, along with a comparison group of individuals who...