Clinical Chemistry
October 1, 2025
Stephanie Marco
Abstract Background Psychedelic and dissociative drugs, including psilocybin, lysergic acid diethylamide (LSD), 3,4-methylenedioxymethamphetamine (MDMA), and ketamine, have garnered significant interest for their therapeutic potential in treating various mental health disorders. However, their psychoactive properties pose substantial risks when used in contexts requiring unimpaired cognitive...
Clinical Chemistry
October 1, 2025
P. Gyawali, C. Suthaharen, J. Chung
Nitrous oxide (N2O or laughing gas) has been used for many legitimate medical, commercial, and industrial purposes. Recreational use of N2O via ‘Whippit’ or ‘nangs’ is on the rise. Prolonged use of N2O can very rapidly cause functional inactivation of Vitamin B12, leading to disabling neuropsychiatric sequelae. Early diagnosis and vitamin B12 replacement is critical to reducing residual...
Clinical Chemistry
March 7, 2023
Steven W. Cotten, Frederick G. Strathmann, Frederick S. Barrett et al.
The clinical evaluation of hallucinogens and other small molecules, conventionally termed psychedelics, has seen a dramatic increase in the past 5 years. Several key clinical trials recently demonstrated the potential efficacy of these compounds in treating a variety of mental health conditions including depression, anxiety, and substance use disorders. Concurrently, the business and patent...
Clinical Chemistry
July 1, 1999
John K. Fallon, Andrew T. Kicman, J. A. Henry et al.
137 citations
Abstract Background: Little is known concerning the enantioselective disposition of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) in humans. In addition, the potential of utilizing the stereochemical composition of an analyte in biological media for forensic purposes requires investigation. Methods: The enantiomers of MDMA and its demethylated metabolite, 3,4-methylenedioxyamphetamine...
Clinical Chemistry
April 1, 1997
Detlef Ritter, Cherise M Cortese, Linda C Edwards et al.
24 citations
Abstract We found a high rate (4.2%) of positive results for lysergic acid diethylamide (LSD) by Emit in 1898 urine samples that were submitted primarily from psychiatric patients for drugs-of-abuse (DOA) testing. Specimens that tested positive for LSD by Emit subsequently tested negative for LSD with two RIAs. Furthermore, LSD was not detected in randomly selected Emit-positive urine samples...
Clinical Chemistry
May 1, 1988
José Manuel Ramos, Robert L. Fitzgerald, Alphonse Poklis
10 citations
Journal Article MDMA and MDA cross reactivity observed with Abbott TDx amphetamine/methamphetamine reagents. Get access J M Ramos, Jr, J M Ramos, Jr Dept. of Pathol., Med. College of Virginia, Virginia Commonwealth University, Richmond 23298 Search for other works by this author on: Oxford Academic Google Scholar R L Fitzgerald, R L Fitzgerald Dept. of Pathol., Med. College of Virginia,...