Revista fisio&terapiaOctober 8, 2025Maurício Pedro Luciano da Costa, Pedro Bruschi Peiretti, Pedro Vinicius Rodrigues Silveira Silva et al.
A resurgence of scientific and clinical interest in psychedelic-assisted therapies, particularly with Psilocybin, has been observed. This paper presents an integrative literature review aiming to identify the scientific contributions, potential benefits, and limitations of the therapeutic use of psilocybin in mental health. The study followed a rigorous protocol. Searches were conducted in the...
Consciousness remains one of the most profound unsolved problems in science, particularly regarding the persistence of a unique self across disruption, duplication, or time. Existing frameworks—Global Neuronal Workspace Theory (GNWT), Integrated Information Theory (IIT), and Orchestrated Objective Reduction (Orch-OR)—describe mechanisms of awareness but fail to explain continuity and uniqueness...
Hallucinations figure prominently in a range of psychiatric disorders but, to date, their developmental origins are not well understood. The aim of the present article is to explore how ideas from mainstream developmental psychology can enhance understanding of how hallucinations develop in different modalities across the lifecourse. Hallucinations vary in their clinical significance depending...
Psilocybin, and its active metabolite psilocin, have seen renewed interest due to studies suggesting potential therapeutic utility. 5-Hydroxytryptamine2A receptors (5-HT 2A Rs) are primary mediators of the psychoactive effects of psychedelics in animals and humans, but the underlying neurobiological mechanisms remain poorly understood. Functional magnetic resonance imaging identified...
NeuroscienceOctober 5, 2025Jannik Nicklas Eliasen, Amir Rezagholizadeh, Helene Påbøl Jacobsen et al.1 citation
Depression and substance use disorder affect millions world-wide, and risk factors include sex. Conventional pharmacotherapies show at best a 50 % success rate. Psychedelics exhibit both anti-addictive and anti-depressive properties. One of these, ibogaine, a root bark sourced alkaloid, interacts with receptors implicated in anti-depressive and anti-addictive effects with affinities in the...
This study examines how psychedelic drug users construct symbolic boundaries to differentiate themselves from other drug users. Drawing on 32 semi-structured interviews with people who have used psychedelic drugs, we explore how participants construct their psychedelic use as distinct from, and superior to, other forms of drug use. Participants differentiate themselves from “hard” drug users in...
There is a long tradition of (attempts at) bridging language and consciousness. Both are human-specific traits, even with precursors in other species, and both are intimately intertwined. Putting it very roughly, human consciousness can be construed, to a large extent, as a sort of inner speech (Morin, 2009; Skipper, 2022). By contrast, the most developed forms of animal consciousness only...
Similar to what happens with other psychedelics, there is an ongoing debate on subjective experience contribution to overall therapeutic mechanisms, which can depend on the targeted conditions. There are very few evidences from controlled studies, limiting the conclusions on safety and efficacy. On top of that, ayahuasca highly variable composition posits another challenge, and studies using...
Background: Pregnancy is a vulnerable period for women, with an increased risk of mental health issues such as depression and anxiety. The perinatal period is particularly important, as maternal mental health significantly impacts maternal physical health, pregnancy outcomes, postnatal outcomes, and fetal and infant development. Psychotherapeutic interventions for depression are essential,...
Nonprescribed use of ketamine has increased worldwide due to its hallucinogenic and psychedelic effects. Ketamine use disorders (KUDs) are marked by intense cravings and tolerance, which often trigger relapses and worsen recovery outcomes, defined as sustained ketamine abstinence with reduced cravings, resolved withdrawal symptoms, and improved psychosocial functioning. Currently, there are no...