Journal of Psychopharmacology
October 16, 2025
Gerard J. Marek, Soma Makai‐bölöni, Daniel Umbricht et al.
2 citations
Background: The treatment of major depressive disorder (MDD) with available antidepressant drugs is characterized by considerable ineffectiveness. Classical psychedelics such as psilocybin and N,N-dimethyltryptamine (DMT), which act primarily as 5-hydroxytryptamine 2A (5-HT 2A ) receptor agonists, have shown preliminary efficacy for inducing long-term remission in MDD after one or two doses....
Russian Journal of Philosophical Sciences
October 15, 2025
A. K. Marinosyan
The article explores the challenges of applying philosophical and neuroscientific theories of consciousness to artificial intelligence (AI) architectures, particularly large language models (LLMs). It argues that most of these theories were developed to explain biological consciousness and therefore cannot be seamlessly mapped onto artificial systems without risking oversimplified or unfounded...
Medicina (Kaunas, Lithuania)
October 15, 2025
Gediminas Gumbis, Kristijonas Puteikis, Rūta Mameniškienė
Background and Objectives: While sleep paralysis (SP) is a well-defined disorder, its pathophysiology and causes remain elusive. We aimed to assess the prevalence of sleep paralysis among higher education students and determine factors associated with SP with a focus on psychoactive substance and medication use. Materials and Methods: We conducted a cross-sectional online survey across higher...
bioRxiv (Cold Spring Harbor Laboratory)
October 15, 2025
Sheida Shadani, Erika Greaves, Zane B. Andrews et al.
preprint
Abstract Psychedelics, particularly psilocybin, have shown therapeutic potential across several psychiatric conditions, including depression, anxiety, obsessive-compulsive disorder, and anorexia nervosa (AN). These disorders often share social deficits that may be effectively alleviated by psychedelics considering their use has been linked with emotional empathy and enhanced social cognition....
bioRxiv : the preprint server for biology
October 15, 2025
Rolf J. Skyberg, Christopher W Fields, Dylan M. Martins et al.
preprint
Psychedelic compounds have the ability to generate altered states of consciousness and profoundly distort perception, often resulting in visual hallucinations. While psychedelics have recently regained attention for their potential cognitive and therapeutic effects, how these drugs affect visual processing to generate visual distortions and hallucinations is not as well characterized....
LIFE International Journal of Health and Life-Sciences
October 14, 2025
Dustin Warden
This case study documents the integrative treatment of a woman with chronic schizophrenia, complex PTSD, and comorbid anxiety and depression, incarcerated during the COVID-19 pandemic. Her primary symptoms included persistent hallucinations, trauma-driven nightmares, and emotional dysregulation. Traumatic themes of incest, supernatural forces, and violent dream figures dominated her inner...
Psychedelics
October 14, 2025
Mingming Zhao, Jianjun Yang, Kenji Hashimoto
MDMA, 3,4-methylenedioxymethamphetamine (“ecstasy,” “molly”), is a distinctive entactogen that reverses the serotonin (5-HT) transporter to increase synaptic 5-HT, while also engaging catecholaminergic and oxytocinergic pathways. In clinical trials, MDMA-assisted psychotherapy has yielded substantial improvements in treatment-resistant posttraumatic stress disorder (PTSD), although regulatory...
Phenomenology and the Cognitive Sciences
October 13, 2025
Francesca Righetti
Why should we be interested in the relationship between dreaming and memory?Dreaming and Memory: Philosophical Issues sets out to explore this issue, offering rigorous and thought-provoking investigations into how these two phenomena might illuminate one another.Bringing together a range of philosophical perspectives, the volume navigates the blurred boundaries of these two cognitive...
International Journal For Multidisciplinary Research
October 13, 2025
Nguyen THI TOT -, Pallabi Mukherjee -
Abstract This article frames the Noble Eightfold Path as a rigorously engineered method, a "technology" for diagnosing, reducing, and ultimately ceasing dukkha (unsatisfactoriness). Drawing on early discourses, the Path's eight factors are mapped to a three-layer architecture: sīla (ethical reliability) supplies system stability; samādhi (collectedness) delivers performance optimization by...
Elife
October 13, 2025
Guylaine Hoffner, Pablo Castro, Lynn Uhrig et al.
The resting primate brain is traversed by spontaneous functional connectivity patterns that show striking differences between conscious and unconscious states. Transcranial direct current stimulation (tDCS), a non-invasive neuromodulatory technique, can improve signs of consciousness in disorders of consciousness (DOCs); however, can it influence both conscious and unconscious dynamic...