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Mindful Self-Compassion for Veterans with Morally Injurious Experiences and Co-Occurring Posttraumatic Stress Disorder and Substance Use Disorder: A Feasibility Study.

Erica Eaton, Christy Capone, Shannon Reese, M Tracie Shea, J Greg Serpa, Christopher Germer

Journal of dual diagnosis April 1, 2025 DOI: 10.1080/15504263.2025.2474953 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Open-label feasibility and acceptability study Peer reviewed
Sample size 26
Population Male veterans with moral injury and co-occurring PTSD and substance use disorder
Duration 8-week intervention, one-month post-treatment follow-up
Topics Meditation Addiction PTSD
Keywords Moral injury Self-compassion Shame Veterans
Citations 2
Registration NCT03681288
Key points Clinically meaningful increases in self-compassion and decreases in PTSD symptoms, guilt, shame, and drinking days were observed after an 8-week Mindful Self-Compassion group.

Abstract

Objective: This study evaluates the feasibility and acceptability of delivering Mindful Self-Compassion (MSC) to veterans with moral injury and co-occurring PTSD and substance use disorder (PTSD-SUD).

Methods: Veterans (N = 26; M age = 50.92; 100% male) were recruited for an 8-week MSC group. Participants completed measures of self-compassion, guilt, shame, PTSD, and substance use outcomes at baseline, post-treatment, and one-month post-treatment.

Results: The recruitment target was easily met, and dropout rates were low (30.8%) for a comorbid veteran sample. Participants reported satisfaction with the intervention. Clinically meaningful change was examined for self-compassion, trauma-related symptoms, and substance use. A clinically meaningful increase for self-compassion and clinically meaningful decreases in PTSD symptoms, guilt, shame, and number of drinking days were observed.

Conclusions: The open-label design and small sample size preclude conclusions regarding efficacy. However, these preliminary findings are encouraging and suggest further investigation of MSC as a compliment to existing trauma-related therapies (NCT03681288).

Comparable studies

Other non-randomized and open-label trials on PTSD, most cited first.

Study Year Design Participants
Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study. Adults with chronic, treatment-resistant PTSD 2013 Long-term follow-up of a completed trial n = 19
Loving‐Kindness Meditation for Posttraumatic Stress Disorder: A Pilot Study Veterans with posttraumatic stress disorder (PTSD) 2013 Open pilot trial
Effects of Transcendental Meditation in Veterans of Operation Enduring Freedom and Operation Iraqi Freedom With Posttraumatic Stress Disorder: A Pilot Study Veterans from Operation Enduring Freedom or Operation Iraqi Freedom with combat-related... 2011 Uncontrolled pilot study n = 5
MDMA-facilitated cognitive-behavioural conjoint therapy for posttraumatic stress disorder: an uncontrolled trial. Couples in which one partner was diagnosed with PTSD 2020 Pilot study n = 6
Culturally informed research design issues in a study for MDMA-assisted psychotherapy for posttraumatic stress disorder People of color with posttraumatic stress disorder 2019 Phase 2 open-label multisite study

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