Current reviews in clinical and experimental pharmacology
March 3, 2025
Sin Hui Ng, Yu Zhao Lee, Ming Ye Hong et al.
2 citations
Ketamine, a substance used for anesthesia and known for inducing dissociation, can lead to addiction and the development of severe withdrawal symptoms. Ketamine alters brain networks before affecting somesthetic sensation. Ketamine abuse was especially prevalent in East and Southeast Asia, and its popularity has continued to expand globally in recent decades. Ketamine is gaining popularity in...
Pharmacology, Biochemistry, and Behavior
March 1, 2025
Joel S Raymond, Alexander G Athanasopoulos, Connie J Badolato et al.
7 citations
Medications to treat substance use disorders (SUDs) remain suboptimal or, in the case of stimulants and cannabis, non-existent. Many factors have contributed to this paucity, including the biological complexity of addiction, regulatory challenges, and a historical lack of enthusiasm among pharmaceutical companies to commit resources to this disease space. Despite these headwinds, the recent...
Neurobiology of Disease
March 1, 2025
Liubov S. Kalinichenko, Iulia Zoicas, Anne-Marie Bienia et al.
4 citations
Addiction is a chronic and severe mental disorder with high gender- and sex-specificity. However, the pathogenesis of this disorder is not fully elucidated, and no targeted pharmacotherapy is available. A growing body of evidence points out the potential involvement of the ceramide system in the pathophysiology of addiction. A pathogenic pathway for several mental disorders based on the...
Journal of Psychopharmacology
February 28, 2025
Dea Siggaard Stenbæk, Emil Deleuran Poulsen, Marie Katrine Klose Nielsen et al.
15 citations
Background: Psilocybin, a serotonin 2A receptor agonist with psychedelic properties, shows promise as a novel treatment for alcohol use disorder (AUD). While current studies involve two dosing sessions, the effects of a single dose have not been investigated. Aims: To investigate the pharmacokinetics, feasibility, safety and efficacy of single-dose psilocybin therapy in AUD. Methods: This...
Frontiers in Psychology
February 17, 2025
Zhiyu Zhang, Lei Wu, Chuxi Lu et al.
Introduction It is common for college students to suffer from mobile phone addiction, which can seriously affect their physical and mental health. The current study looked at the impact of a brief online mindfulness-based intervention (MBI) on mobile phone addiction to address this problem. The mechanisms behind the influence of trait mindfulness (TM) on this process were also investigated in...
The International Journal of Neuropsychopharmacology
February 12, 2025
*Danilo De Gregorio, Carolina Giulia Ferroni, Noemi Nicosia et al.
Abstract Introduction Alcohol use disorder (AUD) is a major problem that causes significant health and social problem. Pharmacological treatments for AUD are limited in their effectiveness, and new drugs are required (ref). Recently, the potential use of psychedelics as novel therapies in treating mental diseases has come to the forefront in psychiatry. For instance, lysergic acid diethylamide...
Medicina
February 6, 2025
Lavinia Hogea, Dana Cătălina Tabugan, Iuliana Costea et al.
14 citations
Background and Objectives: Substance use disorders (SUDs) affect millions worldwide. Despite increasing drug use, treatment options remain limited. Psychedelic-assisted therapy (PAT), integrating psychedelic substances with psychotherapy, offers a promising alternative by addressing underlying neural mechanisms. Materials and Methods: This review’s purpose is to investigate the current...
Expert Opinion on Pharmacotherapy
February 1, 2025
Alejandra Pulido-Saavedra, Anna Borelli, Razi Kitaneh et al.
Substance use disorders (SUDs) are a public health issue, with only some having FDA-approved indicated treatments and these having high attrition. Consequently, there has been interest in novel interventions (e.g. psychedelics that target 5-HT2A receptors) with some promising results. In this narrative review, we aim to focus on the role of the 5-HT2A receptors on the effectiveness of the...
Journal of Psychopharmacology
February 1, 2025
Sophie-Athéna Chapron, Guilhem Bonazzi, Laura Di Lodovico et al.
5 citations
In the context of the need to increase treatment options for substance use disorders, recent research has evaluated the therapeutic potential of psychedelics. However, there is an incomplete understanding of psychedelics' effects on craving, a core symptom of addictive disorders and a predictor of substance use and relapse. To determine if the use of psychedelics is associated with changes in...
BJPsych international
February 1, 2025
Arun Jha, Bharat Goit, Robin Jha et al.
Drug addiction is rife in Nepal, with a high relapse rate following treatment. Apart from basic psychosocial support, there are no evidence-based aftercare services for individuals in recovery. Recently, mindfulness-based interventions have shown promising results in preventing relapse. We discuss the context, challenges and opportunities of organising a 2-day intensive face-to-face...