Psychoactives
August 30, 2026
Laura Schäffert, Human-Friedrich Unterrainer
Background: Alcohol use disorder (AUD) remains a leading contributor to global morbidity, yet conventional treatments often yield suboptimal outcomes and high relapse rates. Psilocybin-assisted therapy has re-emerged as a potential intervention for substance use disorders, but its effectiveness and safety in AUD specifically remain to be comprehensively evaluated. Objective: To review and...
Frontiers in Psychology
2026
Human-Friedrich Unterrainer
Altered states of consciousness range from psychotic disintegration to mystical union, with oceanic affectivity - experiences of ego dissolution, boundlessness, and affective merging - constituting a central feature. While such states can be induced by psychedelics, they also occur through trauma, meditative practices, or within compulsive addictive cycles. In addition, oceanic states may offer...
Front Hum Neurosci
August 11, 2025
Human-Friedrich Unterrainer
1 citation
Oceanic states of consciousness-characterized by ego dissolution, unity, and timelessness-have long occupied a liminal space between psychopathology and transcendence. This paper explores these states through the interdisciplinary lens of existential neuroscience, integrating insights from psychoanalysis, existentialism, affective neuroscience, and psychedelic research. Starting with the...
Frontiers in Psychiatry
2025
Human-Friedrich Unterrainer
4 citations
This essay employs the Icarus myth as a metaphor to examine the role of transcendence in addiction. Icarus' disregard for boundaries, driven by his quest for transcendence, mirrors the behavior of individuals with addictive tendencies. Addiction, a chronic disorder marked by compulsive substance use or behaviors, is characterized by loss of control, tolerance, withdrawal, and life disruptions....
Frontiers in Psychology
2025
Sarah Straßnig, Tobias Herzl, Afrodita Latifi et al.
3 citations
Oceanic feelings, which reflect a sense of boundlessness, unity but also fragmentation can evoke spiritual experiences and possibly lead to psychosis proneness. This study explores oceanic feelings psychometrically, by examining their connections with spirituality, schizotypy, and personality organization. A sample of 480 adult non-clinical participants (66.2% female) completed an online...