Journal of Psychopharmacology
June 26, 2026
Flavia Giaffone de Paiva Ferreira, João Ariel Bonar Fernandes, Renato Filev et al.
With growing research on the use of psychedelics to treat mental health conditions, greater attention to the psychosocial procedures accompanying substance administration is warranted. This scoping review aims to categorize psychosocial protocols used in research involving psychedelics as psychiatric treatment according to their purpose, denomination, format, therapeutic orientation,...
Frontiers in Psychiatry
June 24, 2026
Kathryn Fletcher, Nadine Ezard, Krista J. Siefried et al.
Background Methamphetamine use disorder (MAUD) is associated with substantial psychiatric and physical morbidity, and current treatment options remain limited. Ketamine-assisted psychotherapy (KAP) has shown promise in substance use disorders, but little is known about how individuals experience and interpret this intervention, particularly in MAUD. Qualitative investigation may provide insight...
Psychotherapy and Psychosomatics
June 19, 2026
Judith Rohde, Tyler M Moore, Kathryn Walker et al.
Ketamine combined with psychotherapy has shown promise in treating posttraumatic stress disorder (PTSD), but predictors of clinical benefit remain unclear. In this systematic review and individual participant data meta-analysis (IPDMA), we examined patient- and treatment-level predictors of PTSD symptom change after combined treatment. Eligible studies combined ketamine with psychotherapy in...
Journal of Clinical Psychology
June 15, 2026
Lucas Cruz, Fernando R. Beserra, Julia M.k. Freind et al.
Recent studies have shown promising results for psychedelics in the treatment of psychiatric disorders. Both in clinical and recreational settings, contextual elements, such as music, can influence the experience of users and may be linked to positive outcomes. This systematic review identifies how music is being selected and used in psychedelisc-assisted psychotherapy (PAP). The search adopted...
Journal of Psychedelic Studies
June 12, 2026
Zuzana Postránecká, Matyáš Lucký, Viktor Mravčík et al.
Abstract The Czech Republic, like many European countries, continues to face significant challenges in treating substance use disorders (SUDs), with high relapse rates and complex comorbidities often linked to trauma and mental illness. Psychedelic-assisted psychotherapy (PAP) has re-emerged internationally as a promising therapeutic modality, although available evidence remains heterogeneous...
Journal of Psychedelic Studies
June 10, 2026
Sina Susanna Schüttler, John Nathaniel Parker, Daniel Münster
Psychedelic therapies are moving from the margins of medicine into clinical practice, bringing unresolved ethical questions to the forefront. Among them, ketamine-assisted psychotherapy (KAP) has gained the widest medical acceptance, particularly for treatment-resistant depression (TRD). In August 2025, this development reached a new stage as Norway became the first country to approve...
Journal of Psychoactive Drugs
June 10, 2026
Jack H Buchanan, Brandon Reynante, Michael T. Dinh et al.
Ketamine-assisted psychotherapy (KAP) is an emerging treatment approach that may enhance ketamine's antidepressant effects through neuroplastic synergism or transformative psychological experience. Despite growing clinical use, real-world KAP practices remain understudied. This cross-sectional survey examined the practices of fifty licensed KAP providers treating depression, recruited from a...
Psychopharmacology
June 10, 2026
Julian Kirsch, Christopher Poppe, Anne Beck et al.
BACKGROUND: Alcohol use disorder (AUD) remains a major global health concern, with high morbidity and mortality and limited long-term treatment success. Psychedelic therapy has re-emerged as a potential novel intervention for AUD, yet little is known about how affected individuals perceive such treatments. METHODS: This mixed-method study explored attitudes and perceptions of psychedelic...
Psychoactives
June 8, 2026
Fizza Mitter, Anton Sheptooha, Janni Leung et al.
Post-traumatic stress disorder (PTSD) remains inadequately treated by existing pharmacological and psychological interventions, prompting growing interest in psychedelic-assisted psychotherapy. Although randomised controlled trials have evaluated several psychedelic agents for PTSD, to our knowledge, no prior PTSD-specific synthesis has quantitatively examined multiple agent classes within a...
Healthcare (Basel, Switzerland)
June 5, 2026
Elise C. Tarbi, Ian Bhatia, Nabil Balach et al.
Background: Understanding the benefits of psychedelic-assisted therapy (PAT) will require scientific attention to the causal interaction between the therapeutic context and process. Measuring what actually happens during PAT in large-scale studies will be an essential component of this work. Objective: We aim to develop and preliminarily evaluate the feasibility and reliability of a direct...
Journal of Psychedelic Studies
June 2, 2026
Brandon Reynante, Jack H Buchanan
Abstract Background and Aims Music has been associated with psychedelic experiences throughout human history, from ancient shamanic healing rituals to contemporary psychedelic-assisted therapy (PAT), and is considered integral for positive therapeutic outcomes. Yet optimized protocols and best practice standards for the use of music in PAT are lacking. Methods This interdisciplinary literature...
The International Journal of Neuropsychopharmacology
June 2, 2026
John R. Kelly, Christopher Sheridan, Patricia Iusan et al.
Classical serotonergic psychedelics, such as psilocybin, show emerging evidence of therapeutic potential across a range of mental health disorders, including depression, anxiety, and substance use disorders, with indications of transdiagnostic efficacy. While early-phase studies yielded encouraging results, recent larger-scale phase 3 trials, such as those evaluating psilocybin for...
Psychotherapy (Chicago, Ill.)
June 1, 2026
Roman Palitsky, Laura E Captari, Jessica L Maples-Keller et al.
3 citations
Psychedelic-assisted therapies (PAT) can provoke personally meaningful spiritual or existential experiences in patients; these experiences have been associated with improved outcomes across several treatment targets and populations. The need for spiritual and religious competence, though present across the spectrum of psychotherapeutic practice, is especially strong in psychedelic-assisted...
Brain and Behavior
June 1, 2026
Aloysius Amos Lau, Shalini Arunogiri, Boen Raner-Galutera et al.
1 citation
Peer Support Workers (PSWs) in mental health and substance use treatment draw on their lived experience (LE) to support clients through mutual understanding and trust. Psychedelic-assisted therapy (PAT) is emerging as a mental health and substance use treatment modality. As interest grows, understanding PSWs' perspectives on PAT is critical to inform safe and effective implementation, and the...
Pakistan journal of biological sciences : PJBS
June 1, 2026
Mai Albaik, Ayesha Hanin Shaikh, Haneen Kadi et al.
Background and Objective: Psychedelic substances have re-emerged as promising tools in mental health treatment, yet their integration into clinical practice is influenced by public and professional perceptions. In Saudi Arabia, research on knowledge and attitudes toward psychedelic science remains scarce, particularly among future healthcare professionals. This study assesses and compares the...
Journal of Traumatic Stress
June 1, 2026
Kadek Suhardita, Veno Dwi Krisnanda, Rikas Saputra et al.
In this commentary on Morland et al. (2026)'s recent State of the Science article on 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for posttraumatic stress disorder (PTSD), we aim to emphasize both MDMA's therapeutic promise and its unresolved scientific challenges. Although recent trials on MDMA-assisted interventions have reported encouraging reductions in PTSD symptoms, the...
Psychedelic medicine (New Rochelle, N.Y.)
June 1, 2026
Sara N Lappan, Sean D Davis
Psychedelic-assisted psychotherapy has demonstrated efficacy in treating individual mental health conditions such as addiction, anxiety, depression, and post-traumatic stress disorder. However, current research predominantly focuses on individual experiences, overlooking the relational and systemic factors that influence healing and long-term therapeutic outcomes. This conceptual article...
Psychodynamic psychiatry
June 1, 2026
Christopher W. T. Miller, Zofia Kozak
There has been an increasing interest in the use of classic psychedelics (such as psilocybin) and 3,4-methylenedioxymethamphetamine (MDMA) for treating mental health conditions. Individuals often describe psychedelic sessions as among the most significant experiences in their lives, emphasizing the sense of awe, connectedness, and spiritual transformation taking place. While the psychedelic...
Psychedelic medicine (New Rochelle, N.Y.)
June 1, 2026
William E Rosa, Stephanie Napolitano, Natalie Mcandrew et al.
Psilocybin shows encouraging outcomes for patients with cancer and major depressive disorder (MDD). However, there is insufficient evidence on the use of evidence-based psychotherapeutic interventions to consistently guide and standardize psilocybin preparation, dosing, and integration. Meaning-centered psychotherapy (MCP) is a manualized, brief psychotherapeutic intervention that enhances...
Brain and Behavior
June 1, 2026
T Rowe, T Hurzeler, Ellen Towers et al.
1 citation
Psychedelics have received considerable attention due to their potential in treating psychiatric disorders. The "setting" during psychedelic-assisted therapy (PAT) is recognized as playing a central role in the experience, during which music features prominently. Although music is theorized as directing and shaping psychedelic sessions, its precise contribution to acute experience and...