The Secondary Conditioned Response of Rats and the Effects of Some Psychopharmacological Agents
Journal of Pharmacy and Pharmacology September 1, 1959 DOI: 10.1111/j.2042-7158.1959.tb12535.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Chlorpromazine promazine reserpine morphine meprobamate hydroxyzine azacyclonol phenaglycodol phenobarbitone sodium mescaline iproniazid barbitone sodium glutethimide L1458 mephenesin |
| Topics | Mescaline |
| Keywords | Avoidance response Chlorpromazine Iproniazid Pharmacology Chlordiazepoxide Meprobamate Hydroxyzine Reserpine Amphetamine Tetrabenazine Conditioning Diazepam |
| Citations | 58 |
| Key findings | Chlorpromazine, promazine, reserpine, and morphine block both primary and secondary avoidance conditioned responses at non-motor-impairing doses, while meprobamate, hydroxyzine, azacyclonol, phenaglycodol, and phenobarbitone sodium suppress only the secondary conditioned response. |
Abstract
Abstract The secondary conditioned response has been studied in rats in an experimental avoidance situation. The activity of seventeen drugs has been tested upon the secondary conditioned response developed on a stable basis after an appropriate period of training. Chlorpromazine, promazine, reserpine and morphine block the secondary avoidance conditioned response as well as the usual avoidance conditioned response, in doses not affecting the motor function. Meprobamate, hydroxyzine, azacyclonol, phenaglycodol and phenobarbitone sodium have no specific inhibitory action on the avoidance conditioned response, but suppress the secondary conditioned response. A specific depression of conditioned behaviour is also produced by mescaline and iproniazid. Barbitone sodium, glutethimide, L1458 and mephenesin inhibit the conditioned responses only at neurotoxic doses. On the basis of these findings a new classification of “tranquillising agents” is proposed. It is also suggested that the systematic study of the secondary conditioned avoidance response of rats, may provide a useful experimental approach for studying the specific behavioural action of drugs.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |