A crystallographic and theoretical study of the conformation of DOET and its significance for the hallucinogenic amphetamines
Alan S. Horn, Michael L. Post, Olga Kennard, L. Riva Di Sanseverino
Journal of Pharmacy and Pharmacology 1975 DOI: 10.1111/j.2042-7158.1975.tb09371.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | X-ray crystallography with computational modeling Peer reviewed |
|---|---|
| Topics | Mescaline |
| Keywords | Side chain Ring chemistry Crystallography Crystal structure Hydrogen bond Crystal programming language Stereochemistry Molecule Hallucinogen Organic chemistry |
| Citations | 4 |
| Key points | The crystal structure of DOET shows no hydrogen bonding and a side chain conformation with six low-energy minima, one matching the solid-state position. |
Abstract
Abstract The crystal and molecular structure of 2,5-dimethoxy-4-ethyl-α-methyl-phenylethylamine (DOET) has been determined by X-ray crystallography and the conformation of the side chain has been examined theoretically by the use of a potential energy calculation. There is no indication in the solid state of any intra or inter-molecular hydrogen bonding. The isopropylamine side chain is staggered to the plane of the benzene ring. The α-methyl group is fully extended (antiplanar) whereas the amino group is orientated back towards the ring (synclinal). The potential energy calculations show the existence of 6 minima, one of which corresponds to the crystal position. The calculations also show that the energy differences between the various minima of the side chain are very small. The relationship of these data to the conformations of the hallucinogens, mescaline and 2,4,5,-trimethoxyamphetamine is discussed.