Ascorbic acid antagonizes the behavioural effects of LSD in cats.
Michael E. Trulson, Terriann Crisp, Leslie J. Henderson
The Journal of pharmacy and pharmacology December 1, 1985 DOI: 10.1111/j.2042-7158.1985.tb05009.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Cats |
| Intervention | Ascorbic acid |
| Dose | 500 mg/kg i.p. |
| Topics | LSD |
| Key findings | Pretreatment with ascorbic acid antagonized the behavioral effects of LSD and apomorphine, but not 5-methoxy-N,N-dimethyltryptamine, in cats. |
Abstract
Pretreatment with ascorbic acid (500 mg kg-1 i.p.) antagonized the behavioural effects of lysergic acid diethylamide (LSD) and apomorphine, but not 5-methoxy-N,N-dimethyltryptamine, in cats. The data support the hypothesis that these behavioural effects in cats are due to drug action at both 5-HT and dopamine receptors, and that the action of LSD at dopamine receptors is modulated by ascorbic acid.