A STEREOTYPED RESPONSE INDUCED BY MESCALINE IN MICE AS A MEANS OF INVESTIGATING THE PROPERTIES OF DRUGS ACTING ON THE CNS
G Maffii, E Soncin
Journal of Pharmacy and Pharmacology September 1, 1958 DOI: 10.1111/j.2042-7158.1958.tb10339.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice |
| Interventions | Promazine Hexobarbitone Pentobarbitone Phenobarbitone Meprobamate Mephenesin L 1458 Azacyclonol Atropine Morphine |
| Topics | Mescaline |
| Keywords | Meprobamate Atropine Chlordiazepoxide Pharmacology Promazine Avoidance response Diazepam Morphine Strychnine Anesthesia |
| Citations | 8 |
| Key findings | Chlorpromazine shows the highest specificity in blocking the stereotyped response induced by mescaline in mice. |
Abstract
Abstract The effects of mescaline on spontaneous activity of mice placed in special cages have been studied. The typical response (stereotyped response) has been recorded and assessed in terms of percentage of animals showing the effect. Among drugs affecting the response chloropromazine shows the highest specificity. Promazine, hexobarbitone and pentobarbitone also show a definite but minor effect in doses that do not impair motor function. The response is little affected by phenobarbitone. Meprobamate, mephenesin and a thiadiazole derivative (L 1458) at non-paralyzing doses, and also azacyclonol, do not produce specific antagonistic effects. Nor is the effect significantly influenced by atropine, but it is enhanced by morphine.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |
Citations in the library
Cited by 2
Cites 3
- A Pharmacologic Analysis of the Functions of the Spontaneous Electrical Activity of the Cerebral Cortex The Journal of Nervous and Mental Disease September 1, 1954
- Frenquel, a Blocking Agent Against Experimental LSD‐25 and Mescaline Psychosis Neurology May 1, 1955
- Effects of Mescaline in Laboratory Animals and Influence of Ataraxics on Mescaline-Response Experimental Biology and Medicine June 1, 1956