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Examination of the hallucinogen 2,5-dimethoxy-4-methylamphetamine

G F Phillips, R J Mesley

Journal of Pharmacy and Pharmacology 1969 DOI: 10.1111/j.2042-7158.1969.tb08122.x (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Laboratory study Peer reviewed
Key points The hallucinogenic drug STP is 2,5-dimethoxy-4-methylamphetamine (DOM), which is up to 50 times more potent than mescaline in animal behavioral tests.

Abstract

Abstract Physical characteristics are reported for a tablet form of a new hallucinogenic drug previously circulating in the USA under the name “STP”. High resolution mass, nmr, ultraviolet and infrared spectrometric evidence, which identify the extracted base as 2,5-dimethoxy-4-methylamphetamine, and its chromatographic behaviour, are compared with the experimental compound “DOM”. Polymorphic modifications exhibiting distinct solid phase infrared spectra have been studied by X-ray diffraction and by differential calorimetry. Animal behavioural tests indicate that the psychotomimetic activity of the base is comparable with mescaline but up to 50 times more potent.