Ring-substituted beta-methoxyphenethylamines: a new class of psychotomimetic agents active in man.
D Lemaire, Peyton Jacob, Alexander T. Shulgin
The Journal of pharmacy and pharmacology August 1985 DOI: 10.1111/j.2042-7158.1985.tb03072.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Key points | Four beta-methoxy beta-phenethylamine compounds were synthesized and evaluated in humans as the first reported psychotomimetics structurally analogous to noradrenaline. They were more potent than the corresponding phenethylamines lacking the beta-methoxy group but less potent than the correspondingly substituted amphetamine derivatives. |
Abstract
Four members of a new class of psychotomimetic agents have been synthesized and evaluated in man. These compounds, which incorporate a beta-methoxy group onto a beta-phenethylamine sidechain, are the first reported psychotomimetics which are structural analogues of the neurotransmitter noradrenaline. These substances are more potent than the corresponding phenethylamines (lacking a beta-methoxy group) but less potent than the correspondingly substituted amphetamine derivatives.