PLoS One
2024
David L Lentz, Trinity L Hamilton, Stephanie A Meyers et al.
6 citations
For millennia, healing and psychoactive plants have been part of the medicinal and ceremonial fabric of elaborate rituals and everyday religious practices throughout Mesoamerica. Despite the essential nature of these ritual practices to the societal framework of past cultures, a clear understanding of the ceremonial life of the ancient Maya remains stubbornly elusive. Here we record the...
PLoS One
2024
Erik Jönhagen, Tim Wood, Maria Niemi et al.
5 citations
With the increasing interest in mindfulness practices within clinical as well as non-clinical settings and the increasing body of research on the positive effects of mindfulness, concerns have been raised that mindfulness might also produce adverse effects including intense experiences and psychosis. The aim of this study was to investigate if intense experiences occur as a natural part of...
PLoS One
2024
Michele F. Rodrigues, Larissa Junkes, Jose Appolinario et al.
5 citations
Major Depressive Disorder (MDD) is a global health issue, and a significant portion of individuals with MDD experience Treatment-Resistant Depression (TRD), characterized by the lack of response to adequately trialed antidepressant medication and therapy. This systematic review aims to investigate the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) as an intervention for individuals...
PLoS One
2024
Filip Stanicic, Vladimir Zah, Dimitrije Grbic et al.
4 citations
To explore the cost-effectiveness of midomafetamine-assisted therapy (MDMA-AT) compared to placebo with therapy (PT) in US healthcare settings. A health state-transition model was used to analyze the cost-effectiveness of MDMA-AT for treating patients with chronic PTSD of moderate or higher severity. Both treatment arms consisted of 3 preparation (90-min), 3 interventional (8-h), and 9...
PLoS One
2024
Elena Argento, Tashia Petker, Jayesh Vig et al.
3 citations
This study explores therapists' perspectives on experiential learning, competencies, and training in ketamine-assisted therapy (KAT), a form of psychedelic-assisted therapy (PAT). We aim to understand how therapists' personal psychedelic experiences influence their self-perceived competency and therapeutic relationships regarding KAT. Licensed therapists from Numinus Wellness clinics in Canada...
PLoS One
2024
Nicholas Hagger-Vaughan, Daniel Kolnier, Johan F. Storm
2 citations
Here we describe a type of depolarising plateau potentials (PPs; sustained depolarisations outlasting the stimuli) in layer 2/3 pyramidal cells (L2/3PC) in rat prefrontal cortex (PFC) slices, using whole-cell somatic recordings. To our knowledge, this PP type has not been described before. In particular, unlike previously described plateau potentials that originate in the large apical dendrite...
PLoS One
2024
Josh Martin, Fatemeh Gholamali Nezhad, Alice Rueda et al.
2 citations
Ketamine has recently attracted considerable attention for its rapid effects on patients with major depressive disorder, including treatment-resistant depression (TRD). Despite ketamine's promising results in treating depression, a significant number of patients do not respond to the treatment, and predicting who will benefit remains a challenge. Although its antidepressant effects are known to...
PLoS One
2024
Antoine Grigis, Chloé Gomez, Vincent Frouin et al.
1 citation
Functional connectivity (FC) of resting-state fMRI time series can be estimated using methods that differ in their temporal sensitivity (static vs. dynamic) and the number of regions included in the connectivity estimation (derived from a prior atlas). This paper presents a novel framework for identifying and quantifying resting-state networks using resting-state fMRI recordings. The study...
PLoS One
2024
Kristen M Lee, Bita Ghanei, A Janet Tomiyama
1 citation
Weight stigma is highly prevalent. However, existing weight stigma interventions are only modestly effective at reducing anti-fat attitudes. The current research proposes a novel approach using a loving kindness meditation (LKM). Experiment 1 tests whether random assignment to the LKM intervention reduces explicit and implicit anti-fat bias and increases empathy based on the LKM recipient with...
PLoS One
2024
Benjamin A. Korman
Recent studies on classic psychedelics have suggested that their use is associated with psychological strengths and resilience, thereby conferring users a type of psychological protection relative to non-users. However, this idea has been brought into question by recent findings suggesting that lifetime users of lysergic acid diethylamide (LSD) report worse mental health during stressful...
PLoS One
2024
Kunal R Desai, Patricia O'Malley, Emily Van Culin
To investigate whether Heartfulness meditation practice, compared to Gratitude practice, leads to measurable changes in mental wellbeing among healthcare providers across the US. Participants were randomly assigned to one of the following 6-week interventions: the trainer-guided virtual Heartfulness meditation program or the podcast-based self-guided gratitude practice group. The Professional...
PLoS One
2024
Zhangyi Wang, Yue Zhu, Tingrui Wang et al.
During the Omicron pandemic, clinical first-line nurses played a crucial role in healthcare. Their innovative behavior enhanced the quality of nursing and served as a vital factor in driving the sustainable development of the nursing discipline and healthcare industry. Many previous studies have confirmed the significance of nurses' innovative behavior worldwide. However, the correlations among...
PLoS One
2024
Karim S Ladha, Jiwon Lee, Gabriella Mattina et al.
Nitrous oxide has shown potentially as an efficacious intervention for treatment-resistant depression, yet there remains insufficient evidence pertaining to repeated administration of nitrous oxide over time and active placebo-controlled studies with optimal blinding. Thus, we aim to examine the feasibility and preliminary efficacy of a six-week follow up study examining the effects of a 4 week...
PLoS One
2024
Ig Ibert Bittencourt, Leogildo Freires, Yu Lu et al.
"Flow experience" is a term used to describe the state of being fully immersed in what you are doing. The Flow State Scale (FSS-2) was developed to assess how people feel when they are in the flow state while participating in certain sports activities. The goal of this study was to obtain a short adapted version of the FSS-2 for the Brazilian-Portuguese language and for general activities...
PLoS One
2024
Wolf Mehling, Irina A Strigo, Veronica Goldman et al.
People commonly cope with chronic low back pain (cLBP) by ignoring and distraction. Can mindful interoceptive exposure to the pain sensation itself and its phenomenological components be an alternative approach? Single-arm feasibility study in patients with cLBP using a 2-minute attention exercise guided by a smartphone app several times per day over 8 weeks. We assessed feasibility, pre/post...
PLoS One
2024
Mark J H Lim, Rajan Iyyalol, Joseph W Y Lee et al.
Abnormally widened spatial and temporal binding windows (SBW/TBWs; length of space/time whereby stimuli are considered part of the same percept) are observed in schizophrenia. TBW alterations have been associated with altered sense of agency (hereafter referred to as agency), and an associative relationship between embodiment (body ownership) and agency has been proposed. SBWs/TBWs are...
PLoS One
December 14, 2023
Virginia Fedrigo, Matteo M. Galizzi, Rob Jenkins et al.
Thoughts shape our experience, choice, and behaviour throughout the day. Yet the content of 'penumbral thoughts'-first thoughts upon waking-has received very little research attention. Across seven independent samples (total N = 829), we used recall and reflection methods, solicited the same day, to understand what individuals think as they regain consciousness. These penumbral thoughts show...
PLoS One
October 24, 2023
Jules Evans, Oliver Robinson, Eirini K. Argyri et al.
166 citations
Long-term adverse experiences following psychedelic use can persist for weeks, months, or even years, and are relatively unexplored in psychedelic research. Our convergent mixed-method study gained quantitative and qualitative data from 608 participants who reported extended difficulties following psychedelic experiences. Data was gathered on the context of use, the nature and duration of the...
PLoS One
October 6, 2023
Markus Kiefer, Verena Frühauf, Thomas Kammer
Within consciousness research, the most appropriate assessment of visual awareness is matter of a controversial debate: Subjective measures rely on introspections of the observer related to perceptual experiences, whereas objective measures are based on performance of the observer to accurately detect or discriminate the stimulus in question across a series of trials. In the present study, we...
PLoS One
March 22, 2023
W. Crone, Pelin Kesebir, Beverly Hays et al.
The mental health crisis in graduate education combined with low treatment rates among engineering graduate students underscores the need for engineering graduate programs to provide effective methods to promote well-being. There is an extensive body of neuroscience research showing that contemplative practices, such as mindfulness, produce measurable effects on brain function and overall...
PLoS One
March 15, 2023
Rita Sleimen-Malkoun, Louise Devillers-Réolon, J. Temprado
The present study investigated acute cognitive effects of mindfulness meditation (MM) compared to an active control intervention in meditators (n = 22) and novices (n = 20) using a within-subject design. We analyzed reaction times in a digitized Stroop task at baseline, after a 10-minute MM session with a fundamental breathing exercise, and after a 10-minute attentive listening intervention....
PLoS One
February 10, 2023
Lucia Melloni, Liad Mudrik, Michael Pitts et al.
106 citations
The relationship between conscious experience and brain activity has intrigued scientists and philosophers for centuries. In the last decades, several theories have suggested different accounts for these relationships. These theories have developed in parallel, with little to no cross-talk among them. To advance research on consciousness, we established an adversarial collaboration between...
PLoS One
January 20, 2023
The effects of short interventions of focused-attention vs. self-compassion mindfulness meditation on undergraduate students: Evidence from self-report, classroom performance, and ERPs.
PLoS One
2023
Edie L Sperling, Jennifer M Hulett, Leeanne B Sherwin et al.
38 citations
Medical students have high levels of stress, which is associated with higher incidents of burnout, depression, and suicide compared to age-matched peers. Mindfulness practices have been shown to reduce stress among medical students. The purpose of this systematic review and meta-analysis was to examine if mindfulness interventions have an overall effect on stress outcomes in the high-stress...
PLoS One
2023
Ahmed M Alzahrani, Ahmed Hakami, Ahmad Alhadi et al.
31 citations
There is growing interest in Mindfulness-based Stress Reduction (MBSR) program to combat mental distress in medical students. In Saudi Arabia, literature is insufficient about MBSR and its effectiveness. This study aims to measure the effectiveness of MBSR in improving mindful state, stress, anxiety, and depression in medical students. Also, the study explores the association between the...